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Waelput, W, Brouckaert, P, Broekaert, D, Tavernier, J.
A role for leptin in the systemic inflammatory response syndrome (SIRS) and in immune response
Current Drug Targets Inflamm Allergy 1, 277-289, 2002. (Epub ---)

Ameloot, P, Declercq, W, Fiers, W, Vandenabeele, P, Brouckaert, P.
Heterotrimers formed by tumor necrosis factors of different species or muteins
J Biol Chem 276, 27098-27103, 2001. (Epub 2001 May 22)

Ameloot, P, Fiers, W, De Bleser, P, Ware, CF, Vandenabeele, P, Brouckaert, P.
Identification of tumor necrosis factor (TNF) amino acids crucial for binding to the murine p75 TNF receptor and construction of receptor-selective mutants
J Biol Chem 276, 37426-37430, 2001. (Epub 2001 Jul 11)

Waelput, W, Broekaert, D, Vandekerckhove, J, Brouckaert, P, Tavernier, J, Libert, C.
A mediator role for metallothionein in tumor necrosis factor-induced lethal shock
J Exp Med 194, 1617-1624, 2001. (Epub ---)

Wielockx, B, Hochepied, T, Staelens, J, Van Molle, W, Brouckaert, P, Libert, C.
Detection, characterisation and purification of a murine liver factor capable of desensitising towards the lethal activity of tumour necrosis factor
Cytokine 15, 59-65, 2001. (Epub ---)

Cauwels, A, Van Molle, W, Janssen, B, Everaerdt, B, Huang, P, Fiers, W, Brouckaert, P.
Protection against TNF-induced lethal shock by soluble guanylate cyclase inhibition requires functional inducible nitric oxide synthase
Immunity 13, 223-231, 2000. (Epub ---)

Hochepied, T, Ameloot, P, Brouckaert, P, Van Leuven, F, Libert, C.
Differential response of a2-macroglobulin-deficient mice in models of lethal TNF-induced inflammation
Eur Cytokine Netw 11, 597-601, 2000. (Epub ---)

Van Molle, W, Hochepied, T, Brouckaert, P, Libert, C.
The major acute-phase protein, serum amyloid P component, in mice is not involved in endogenous resistance against tumor necrosis factor alpha-induced lethal hepatitis, shock, and skin necrosis
Infect Immun 68, 5026-5029, 2000. (Epub ---)

Van Molle, W, Vanden Berghe, J, Brouckaert, P, Libert, C.
Tumor necrosis factor-induced lethal hepatitis: Pharmacological intervention with verapamil, tannic acid, picotamide and K76COOH
FEBS Lett 467, 201-205, 2000. (Epub ---)

Libert, C, Wielockx, B, Grijalba, B, Van Molle, W, Kremmer, E, Colten, HR, Fiers, W, Brouckaert, P.
The role of complement activation in tumour necrosis factor-induced lethal hepatitis
Cytokine 11, 617-625, 1999. (Epub ---)

Libert, C, Wielockx, B, Hammond, GL, Brouckaert, P, Fiers, W, Elliott, RW.
Identification of a locus on distal mouse chromosome 12 that controls resistance to tumor necrosis factor-induced lethal shock
Genomics 55, 284-289, 1999. (Epub ---)

Takahashi, N, Waelput, W, Guisez, Y.
Leptin is an endogenous protective protein against the toxicity exerted by tumor necrosis factor
J Exp Med 189, 207-212, 1999. (Epub ---)

Van Molle, W, Brouckaert, P, Libert, C.
Caspase-1 is not involved in experimental hepatitis in mouse
FEBS Lett 445, 115-118, 1999. (Epub ---)

Van Molle, W, Denecker, G, Rodriguez, I, Brouckaert, P, Vandenabeele, P, Libert, C.
Activation of caspases in lethal experimental hepatitis and prevention by acute phase proteins
J Immunol 163, 5235-5241, 1999. (Epub ---)

Brouckaert, P.
Septic shock
In Encyclopedia of Immunology. (Delves, PJ, Roitt, IM, eds.), 2nd ed., London, Academic Press, pp. 2161-2164, 1998. (Epub ---)

Libert, C, Hochepied, T, Berger, FG, Baumann, H, Fiers, W, Brouckaert, P.
High-level constitutive expression of a1-acid glycoprotein and lack of protection against tumor necrosis factor-induced lethal shock in transgenic mice
Transgenic Res 7, 429-435, 1998. (Epub ---)

ter Steege, JCA, van de Ven, MWCM, Forget, PP, Brouckaert, P, Buurman, WA.
The role of endogenous IFN-g, TNF-a and IL-10 in LPS-induced nitric oxide release in a mouse model
Cytokine 10, 115-123, 1998. (Epub ---)

Van Molle, W, Libert, C, Fiers, W, Brouckaert, P.
a1-Acid glycoprotein and a1-antitrypsin inhibit TNF-induced but not anti-Fas-induced apoptosis of hepatocytes in mice
J Immunol 159, 3555-3564, 1997. (Epub ---)

Brouckaert, P, Fiers, W.
Tumor necrosis factor and the systemic inflammatory response syndrome
Curr Top Microbiol Immunol 216, 167-187, 1996. (Epub ---)

Brouckaert, P, Libert, C, Cauwels, A, Everaerdt, B, Van Molle, W, Ameloot, P, Gansemans, Y, Grijalba, B, Takahashi, N, Truong, M-J, Van Leuven, P, Fiers, W.
Inhibition of and sensitization to the lethal effects of tumor necrosis factor
J Inflamm 47, 18-26, 1996. (Epub ---)

Cauwels, A, Fiers, W, Brouckaert, P.
Murine IL-12 is involved in Calmette-Guérin bacillus-induced sensitization and is by itself sufficient to sensitize mice to the lethal effects of human TNF
J Immunol 156, 4686-4690, 1996. (Epub ---)

Libert, C, Van Molle, W, Brouckaert, P, Fiers, W.
a1-Antitrypsin inhibits the lethal response to TNF in mice
J Immunol 157, 5126-5129, 1996. (Epub ---)

Libert, C, Van Molle, W, Brouckaert, P, Fiers, W.
Platelet-activating factor is a mediator in tumor necrosis factor/galactosamine-induced lethality
J Inflamm 46, 139-143, 1996. (Epub ---)

Cauwels, A, Brouckaert, P, Grooten, J, Huang, S, Aguet, M, Fiers, W.
Involvement of IFN-g in Bacillus Calmette-Guérin-induced but not in tumor-induced sensitization to TNF-induced lethality
J Immunol 154, 2753-2763, 1995. (Epub ---)

Takahashi, N, Brouckaert, P, Fiers, W.
Mechanism of tolerance to tumor necrosis factor: Receptor-specific pathway and selectivity
Am J Physiol 269, R398-R405, 1995. (Epub ---)

Takahashi, N, Fiers, W, Brouckaert, P.
Anti-tumor activity of tumor necrosis factor in combination with interferon-gamma is not affected by prior tolerization
Int J Cancer 63, 846-854, 1995. (Epub ---)

Brouckaert, P, Ameloot, P, Cauwels, A, Everaerdt, B, Libert, C, Takahashi, N, Van Molle, W, Fiers, W.
Receptor-selective mutants of tumour necrosis factor in the therapy of cancer: Preclinical studies
Circ Shock 43, 185-190, 1994. (Epub ---)

Everaerdt, B, Brouckaert, P, Fiers, W.
Recombinant IL-1 receptor antagonist protects against TNF-induced lethality in mice
J Immunol 152, 5041-5049, 1994. (Epub ---)

Libert, C, Brouckaert, P, Fiers, W.
Protection by a1-acid glycoprotein against tumor necrosis factor-induced lethality
J Exp Med 180, 1571-1575, 1994. (Epub ---)

Libert, C, Takahashi, N, Cauwels, A, Brouckaert, P, Bluethmann, H, Fiers, W.
Response of interleukin-6-deficient mice to tumor necrosis factor-induced metabolic changes and lethality
Eur J Immunol 24, 2237-2242, 1994. (Epub ---)

Takahashi, N, Brouckaert, P, Bemelmans, MHA, Buurman, WA, Fiers, W.
Mechanism of induction of tolerance to tumour necrosis factor (TNF): No involvement of modulators of TNF bioavailability or receptor binding
Cytokine 6, 235-242, 1994. (Epub ---)

Brouckaert, P, Everaerdt, B, Libert, C, Takahashi, N, Cauwels, A, Fiers, W.
Strategies to broaden the therapeutic margin of tumor necrosis factor
In Tumor Necrosis Factor: Molecular and Cellular Biology and Clinical Relevance. (Fiers, W, Buurman, WA, eds.), Basel, Karger, pp. 226-232, 1993. (Epub ---)

Brouckaert, PG, Libert, C.
Tumor necrosis factor
In Acute Phase Proteins Molecular Biology, Biochemistry, and Clinical Applications. (Mackiewicz, A, Kushner, I, Baumann, H, eds.), Boca Raton, CRC Press, pp. 329-342, 1993. (Epub ---)

Brouckaert, P, Libert, C, Everaerdt, B, Takahashi, N, Cauwels, A, Fiers, W.
Tumor necrosis factor, its receptors and the connection with interleukin 1 and interleukin 6
Immunobiology 187, 317-329, 1993. (Epub ---)

Fiers, W, Beyaert, R, Brouckaert, P, Cauwels, A, Declercq, W, De Valck, D, Everaerdt, B, Goossens, V, Grooten, J, Haegeman, G, Libert, C, Schulze-Osthoff, K, Takahashi, N, Vandenabeele, P, Vanhaesebroeck, B, Van Ostade, X, Van Roy, F.
Two pathways of tumor necrosis factor signal transduction: In vitro and in vivo implications
In Tumor Necrosis Factor: Molecular and Cellular Biology and Clinical Relevance. (Fiers, W, Buurman, WA, eds.), Basel, Karger (Shugar, D, Rode, W, Borowski, E, eds.), Warszawa-Berlin, Polish Scientific Publishers PWN/Springer-Verlag, pp. 58-65, 1993. (Epub ---)

Libert, C, Everaerdt, B, Takahashi, N, Cauwels, A, Brouckaert, P, Fiers, W.
Protection against tumor necrosis factor-induced lethality
In Tumor Necrosis Factor: Molecular and Cellular Biology and Clinical Relevance. (Fiers, W, Buurman, WA, eds.), Basel, Karger, pp. 126-131, 1993. (Epub ---)

Takahashi, N, Brouckaert, P, Fiers, W.
Cyclooxygenase inhibitors prevent the induction of tolerance to the toxic effects of tumor necrosis factor
J Immunother 14, 16-21, 1993. (Epub ---)

Van Ostade, X, Vandenabeele, P, Everaerdt, B, Loetscher, H, Gentz, R, Brockhaus, M, Lesslauer, W, Tavernier, J, Brouckaert, P, Fiers, W.
Human TNF mutants with selective activity on the p55 receptor
Nature 361, 266-269, 1993. (Epub ---)

Brouckaert, P, Everaerdt, B, Fiers, W.
The glucocorticoid antagonist RU38486 mimics interleukin-1 in its sensitization to the lethal and interleukin-6-inducing properties of tumor necrosis factor
Eur J Immunol 22, 981-986, 1992. (Epub ---)

Brouckaert, PGG, Fiers, W, Lejeune, FJ.
Coley's vaccine and TNF therapy
Nature 358, 630, 1992. (Epub ---)

Brouckaert, P, Libert, C, Everaerdt, B, Fiers, W.
Selective species specificity of tumor necrosis factor for toxicity in the mouse
Lymphokine Cytokine Res 11, 193-196, 1992. (Epub ---)

Fiers, W, Beyaert, R, Brouckaert, P, Decoster, E, De Valck, D, Everaerdt, B, Grooten, J, Lenaerts, A, Libert, C, Schulze-Osthoff, K, Takahashi, N, Tavernier, J, Van Bladel, S, Van Dorpe, C, Vanhaesebroeck, B, Van Ostade, X, Van Roy, F.
Tumor necrosis factor: Mechanism of action at the molecular, cellular and in vivo level
In Tumor Necrosis Factor: Structure-function Relationship and Clinical Application. (Osawa, T, Bonavida, B, eds.), Basel, Karger, pp. 66-73, 1992. (Epub ---)

Fiers, W, Beyaert, R, Brouckaert, P, Decoster, E, De Valck, D, Everaerdt, B, Grooten, J, Lenaerts, A, Libert, C, Schulze-Osthoff, K, Takahashi, N, Van Bladel, S, Van Dorpe, C, Vanhaesebroeck, B, Van Ostade, X, Van Roy, F.
Tumor necrosis factor: Mechanism of action and its potential for anticancer therapy
In Molecular Aspects of Chemotherapy. , pp. 119-125, 1992. (Epub ---)

Libert, C, Vink, A, Coulie, P, Brouckaert, P, Everaerdt, B, Van Snick, J, Fiers, W.
Limited involvement of interleukin-6 in the pathogenesis of lethal septic shock as revealed by the effect of monoclonal antibodies against interleukin-6 or its receptor in various murine models
Eur J Immunol 22, 2625-2630, 1992. (Epub ---)

Libert, C, Van Bladel, S, Brouckaert, P, Fiers, W.
The influence of modulating substances on tumor necrosis factor and interleukin-6 levels after injection of murine tumor necrosis factor or lipopolysaccharide in mice
J Immunother 10, 227-235, 1991. (Epub ---)

Libert, C, Van Bladel, S, Brouckaert, P, Shaw, A, Fiers, W.
Involvement of the liver, but not of IL-6, in IL-1-induced desensitization to the lethal effects of tumor necrosis factor
J Immunol 146, 2625-2632, 1991. (Epub ---)

Takahashi, N, Brouckaert, P, Fiers, W.
Induction of tolerance allows separation of lethal and antitumor activities of tumor necrosis factor in mice
Cancer Res 51, 2366-2372, 1991. (Epub ---)

Fiers, W, Beyaert, R, Brouckaert, P, Everaerdt, B, Haegeman, G, Libert, C, Suffys, P, Takahashi, N, Tavernier, J, Van Bladel, S, Vanhaesebroeck, B, Van Ostade, X, Van Roy, F.
In vitro and in vivo action of tumor necrosis factor
In Tumor Necrosis Factor: Structure, Mechanism of Action, Role in Disease and Therapy. (Bonavida, B, Granger, G, eds.), Basel, Karger, pp. 77-81, 1990. (Epub ---)

Fiers, W, Beyaert, R, Brouckaert, P, Everaerdt, B, Libert, C, Suffys, P, Takahashi, N, Vanhaesebroeck, B, Van Roy, F.
Mechanism of action of tumor necrosis factor and its implications for synergizing and antagonizing drugs
In Endotoxin From Pathophysiology to Therapeutic Approaches. (Baumgartner, J-D, Calandra, T, Carlet, J, eds.), Paris, Médecine-Sciences/Flammarion, pp. 59-68, 1990. (Epub ---)

Libert, C, Brouckaert, P, Shaw, A, Fiers, W.
Induction of interleukin 6 by human and murine recombinant interleukin 1 in mice
Eur J Immunol 20, 691-694, 1990. (Epub ---)

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