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Publications from this research unit

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Behrensdorf, HA, Van de Craen, M, Knies, UE, Vandenabeele, P, Clauss, M.
The endothelial monocyte-activating polypeptide II (EMAP II) is a substrate for caspase-7
FEBS Lett 466, 143-147, 2000. (Epub ---)

Boone, E, Vanden Berghe, T, van Loo, G, De Wilde, G, De Wael, N, Vercammen, D, Fiers, W, Haegeman, G, Vandenabeele, P.
Structure/function analysis of p55 tumor necrosis factor receptor and Fas-associated death domain. Effect on necrosis in L929sA cells
J Biol Chem 275, 37596-37603, 2000. (Epub ---)

Daemen, MARC, Heemskerk, VH, van 't Veer, C, Denecker, G, Wolfs, TGAM, Vandenabeele, P, Buurman, WA.
Functional protection by acute phase proteins a1-acid glycoprotein and a1-antitrypsin against ischemia/reperfusion injury by preventing apoptosis and inflammation
Circulation 102, 1420-1426, 2000. (Epub ---)

Daemen, MARC, Vandenabeele, P, Buurman, WA.
How cells die counts
Am J Kidney Dis 36, 665-668, 2000. (Epub ---)

Declercq, W, Logghe, M, Fiers, W, Contreras, R.
Cloning and expression of cytokine genes
In Cytokine Molecular Biology A Practical Approach. (Balkwill, F, ed.), Oxford, University Press, pp. 1-20, 2000. (Epub ---)

Denecker, G, Dooms, H, van Loo, G, Vercammen, D, Grooten, J, Fiers, W, Declercq, W, Vandenabeele, P.
Phosphatidyl serine exposure during apoptosis precedes release of cytochrome c and decrease in mitochondrial transmembrane potential
FEBS Lett 465, 47-52, 2000. (Epub ---)

Eckhart, L, Declercq, W, Ban, J, Rendl, M, Lengauer, B, Mayer, C, Lippens, S, Vandenabeele, P, Tschachler, E.
Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation
J Invest Dermatol 115, 1148-1151, 2000. (Epub ---)

Goossens, V, De Vos, K, Vercammen, D, Steemans, M, Vancompernolle, K, Fiers, W, Vandenabeele, P, Grooten, J.
Role of reactive oxygen species in tumor necrosis factor toxicity
In Antioxidant and Redox Regulation of Genes. (Sen, CK, Sies, H, Baeuerle, PA, eds.), San Diego, Academic Press, pp. 245-264 , 2000. (Epub ---)

Huston, E, Beard, M, McCallum, F, Pyne, NJ, Vandenabeele, P, Scotland, G, Houslay, MD.
The cAMP-specific phosphodiesterase PDE4A5 is cleaved downstream of its SH3 interaction domain by caspase-3. Consequences for altered intracellular distribution
J Biol Chem 275, 28063-28074, 2000. (Epub ---)

Lippens, S, Kockx, M, Knaapen, M, Mortier, L, Polakowska, R, Verheyen, A, Garmyn, M, Zwijsen, A, Formstecher, P, Huylebroeck, D, Vandenabeele, P, Declercq, W.
Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing
Cell Death Differ 7, 1218-1224, 2000. (Epub ---)

Penning, L, Denecker, G, Vercammen, D, Declercq, W, Schipper, RG, Vandenabeele, P.
A role for potassium in TNF-induced apoptosis and gene-induction in human and rodent tumour cell lines
Cytokine 12, 747-750, 2000. (Epub ---)

Pype, S, Declercq, W, Ibrahimi, A, Michiels, C, Van Rietschoten, JGL, Dewulf, N, de Boer, M, Vandenabeele, P, Huylebroeck, D, Remacle, JE.
TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kB activation
J Biol Chem 275, 18586-18593, 2000. (Epub ---)

Assefa, Z, Vantieghem, A, Declercq, W, Vandenabeele, P, Vandenheede, JR, Merlevede, W, de Witte, P, Agostinis, P.
The activation of the c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signaling pathways protects HeLa cells from apoptosis following photodynamic therapy with hypericin
J Biol Chem 274, 8788-8796, 1999. (Epub ---)

Baxter, GT, Kuo, RC, Jupp, OJ, Vandenabeele, P, MacEwan, DJ.
Tumor necrosis factor-alpha mediates both apoptotic cell death and cell proliferation in a human hematopoietic cell line dependent on mitotic activity and receptor subtype expression
J Biol Chem 274, 9539-9547, 1999. (Epub ---)

Daemen, MARC, van 't Veer, C, Denecker, G, Heemskerk, VH, Wolfs, TGAM, Clauss, M, Vandenabeele, P, Buurman, WA.
Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation
J Clin Invest 104, 541-549, 1999. (Epub ---)

De Bleecker, JL, Meire, VI, Declercq, W, Van Aken, EH.
Immunolocalization of tumor necrosis factor-alpha and its receptors in inflammatory myopathies
Neuromusc Disorders 9, 239-246, 1999. (Epub ---)

Eymin, B, Sordet, O, Droin, N, Munsch, B, Haugg, M, Van de Craen, M, Vandenabeele, P, Solary, E.
Caspase-induced proteolysis of the cyclin-dependent kinase inhibitor p27Kip1 mediates its anti-apoptotic activity
Oncogene 18, 4839-4847, 1999. (Epub ---)

Faraco, PR, Ledgerwood, EC, Vandenabeele, P, Prins, JB, Bradley, JR.
Tumor necrosis factor induces distinct patterns of caspase activation in WEHI-164 cells associated with apoptosis or necrosis depending on cell cycle stage
Biochem Biophys Res Commun 261, 385-392, 1999. (Epub ---)

Ferrari, D, Los, M, Bauer, MKA, Vandenabeele, P, Wesselborg, S, Schulze-Osthoff, K.
P2Z purinoreceptor ligation induces activation of caspases with distinct roles in apoptotic and necrotic alterations of cell death
FEBS Lett 447, 71-75, 1999. (Epub ---)

Fiers, W, Beyaert, R, Declercq, W, Vandenabeele, P.
More than one way to die: Apoptosis, necrosis and reactive oxygen damage
Oncogene 18, 7719-7730, 1999. (Epub ---)

Goossens, V, De Vos, K, Vercammen, D, Steemans, M, Vancompernolle, K, Fiers, W, Vandenabeele, P, Grooten, J.
Redox regulation of TNF signaling
BioFactors 10, 145-156, 1999. (Epub ---)

Levi, B, Sica, A, Müller-Newen, G, Takahashi, N, Vandenabeele, P, Fish, E.
Jerusalem of cytokines
Cytokine Growth Factor Rev 10, 159-171, 1999. (Epub ---)

Pattyn, E, Van Ostade, X, Schauvliege, L, Verhee, A, Kalai, M, Vandekerckhove, J, Tavernier, J.
Dimerization of the interferon type I receptor IFNaR2-2 is sufficient for induction of interferon effector genes but not for full antiviral activity
J Biol Chem 274, 34838-34845, 1999. (Epub ---)

Rickers, A, Peters, N, Badock, V, Beyaert, R, Vandenabeele, P, Dörken, B, Bommert, K.
Cleavage of transcription factor SP1 by caspases during anti-IgM-induced B-cell apoptosis
Eur J Biochem 261, 269-274, 1999. (Epub ---)

Schotte, P, Declercq, W, Van Huffel, S, Vandenabeele, P, Beyaert, R.
Non-specific effects of methyl ketone peptide inhibitors of caspases
FEBS Lett 442, 117-121, 1999. (Epub ---)

Van Criekinge, W, Cornelis, S, Van de Craen, M, Vandenabeele, P, Fiers, W, Beyaert, R.
GAL4 is a substrate for caspases: Implications for two-hybrid screening and other GAL4-based assays
Mol Cell Biol Res Commun 1, 158-161, 1999. (Epub ---)

Van de Craen, M, Berx, G, Van den brande, I, Fiers, W, Declercq, W, Vandenabeele, P.
Proteolytic cleavage of beta-catenin by caspases: An in vitro analysis
FEBS Lett 458, 167-170, 1999. (Epub ---)

Van de Craen, M, Declercq, W, Van den brande, I, Fiers, W, Vandenabeele, P.
The proteolytic procaspase activation network: An in vitro analysis
Cell Death Differ 6, 1117-1124, 1999. (Epub ---)

Van de Craen, M, De Jonghe, C, Van den brande, I, Declercq, W, Van Gassen, G, Van Criekinge, W, Vanderhoeven, I, Fiers, W, Van Broeckhoven, C, Hendriks, L, Vandenabeele, P.
Identification of caspases that cleave presenilin-1 and presenilin-2. Five presenilin-1 (PS1) mutations do not alter the sensitivity of PS1 to caspases
FEBS Lett 445, 149-154, 1999. (Epub ---)

Van Molle, W, Denecker, G, Rodriguez, I, Brouckaert, P, Vandenabeele, P, Libert, C.
Activation of caspases in lethal experimental hepatitis and prevention by acute phase proteins
J Immunol 163, 5235-5241, 1999. (Epub ---)

Declercq, W, Denecker, G, Fiers, W, Vandenabeele, P.
Cooperation of both TNF receptors in inducing apoptosis: Involvement of the TNF receptor-associated factor binding domain of the TNF receptor 75
J Immunol 161, 390-399, 1998. (Epub ---)

De Vos, K, Goossens, V, Boone, E, Vercammen, D, Vancompernolle, K, Vandenabeele, P, Haegeman, G, Fiers, W, Grooten, J.
The 55-kDa tumor necrosis factor receptor induces clustering of mitochondria through its membrane-proximal region
J Biol Chem 273, 9673-9680, 1998. (Epub ---)

Penning, LC, Schipper, RG, Vercammen, D, Verhofstad, AAJ, Denecker, T, Beyaert, R, Vandenabeele, P.
Sensitization of TNF-induced apoptosis with polyamine synthesis inhibitors in different human and murine tumour cell lines
Cytokine 10, 423-431, 1998. (Epub ---)

Prins, JB, Ledgerwood, EC, Ameloot, P, Vandenabeele, P, Faraco, PR, Bright, NA, O'Rahilly, S, Bradley, JR.
Tumor necrosis factor-induced cytotoxicity is not related to rates of mitochondrial morphological abnormalities or autophagy-changes that can be mediated by TNFR-I or TNFR-II
Biosci Rep 18, 329-340, 1998. (Epub ---)

Schotte, P, Van Criekinge, W, Van de Craen, M, van Loo, G, Desmedt, M, Grooten, J, Cornelissen, M, De Ridder, L, Vandekerckhove, J, Fiers, W, Vandenabeele, P, Beyaert, R.
Cathepsin B-mediated activation of the proinflammatory caspase-11
Biochem Biophys Res Commun 251, 379-387, 1998. (Epub ---)

Steemans, M, Goossens, V, Van de Craen, M, Van Herreweghe, F, Vancompernolle, K, De Vos, K, Vandenabeele, P, Grooten, J.
A caspase-activated factor (CAF) induces mitochondrial membrane depolarization and cytochrome c release by a nonproteolytic mechanism
J Exp Med 188, 2193-2198, 1998. (Epub ---)

Vancompernolle, K, Van Herreweghe, F, Pynaert, G, Van de Craen, M, De Vos, K, Totty, N, Sterling, A, Fiers, W, Vandenabeele, P, Grooten, J.
Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity
FEBS Lett 438, 150-158, 1998. (Epub ---)

Van Criekinge, W, van Gurp, M, Decoster, E, Schotte, P, Van de Craen, M, Fiers, W, Vandenabeele, P, Beyaert, R.
Use of the yeast three-hybrid system as a tool to study caspases
Anal Biochem 263, 62-66, 1998. (Epub ---)

Van de Craen, M, van Loo, G, Pype, S, Van Criekinge, W, Van den brande, I, Molemans, F, Fiers, W, Declercq, W, Vandenabeele, P.
Identification of a new caspase homologue: Caspase-14
Cell Death Differ 5, 838-846, 1998. (Epub ---)

Van de Craen, M, van Loo, G, Van den brande, I, Declercq, W, Mandruzzato, S, van der Bruggen, P, Fiers, W, Vandenabeele, P.
Molecular cloning and identification of murine caspase-8
J Mol Biol 284, 1017-1026, 1998. (Epub ---)

Vantieghem, A, Assefa, Z, Vandenabeele, P, Declercq, W, Courtois, S, Vandenheede, JR, Merlevede, W, de Witte, P, Agostinis, P.
Hypericin-induced photosensitization of HeLa cells leads to apoptosis or necrosis. Involvement of cytochrome c and procaspase-3 activation in the mechanism of apoptosis
FEBS Lett 440, 19-24, 1998. (Epub ---)

Vercammen, D, Beyaert, R, Denecker, G, Goossens, V, van Loo, G, Declercq, W, Grooten, J, Fiers, W, Vandenabeele, P.
Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor
J Exp Med 187, 1477-1485, 1998. (Epub ---)

Vercammen, D, Brouckaert, G, Denecker, G, Van de Craen, M, Declercq, W, Fiers, W, Vandenabeele, P.
Dual signaling of the Fas receptor: Initiation of both apoptotic and necrotic cell death pathways
J Exp Med 188, 919-930, 1998. (Epub ---)

Barge, RMY, Willemze, R, Vandenabeele, P, Fiers, W, Beyaert, R.
Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth withdrawal
FEBS Lett 409, 207-210, 1997. (Epub ---)

Beyaert, R, Kidd, VJ, Cornelis, S, Van de Craen, M, Denecker, G, Lahti, JM, Gururajan, R, Vandenabeele, P, Fiers, W.
Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor
J Biol Chem 272, 11694-11697, 1997. (Epub ---)

Denecker, G, Vandenabeele, P, Grooten, J, Penning, LC, Declercq, W, Beyaert, R, Buurman, WA, Fiers, W.
Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma
Cytokine 9, 631-638, 1997. (Epub ---)

Dentener, MA, Francot, GJM, Hiemstra, PS, Tool, ATJ, Verhoeven, AJ, Vandenabeele, P, Buurman, WA.
Bactericidal/permeability-increasing protein release in whole blood ex vivo: Strong induction by lipopolysaccharide and tumor necrosis factor-alpha
J Infect Dis 175, 108-117, 1997. (Epub ---)

De Valck, D, Heyninck, K, Van Criekinge, W, Vandenabeele, P, Fiers, W, Beyaert, R.
A20 inhibits NF-kB activation independently of binding to 14-3-3 proteins
Biochem Biophys Res Commun 238, 590-594, 1997. (Epub ---)

Fiers, W, Beyaert, R, Boone, E, Declercq, W, Decoster, E, De Valck, D, Goossens, V, Grooten, J, Haegeman, G, Heyninck, K, Penning, L, Plaisance, S, Van de Craen, M, Vandenabeele, P, Vanden Berghe, W, Vandevoorde, V, Vercammen, D.
Tumour necrosis factor: Intracellular mechanism of action
In HIV and Cytokines. (Guenounou, M, ed.), Paris, INSERM, pp. 33-41 , 1997. (Epub ---)

Lardon, F, Snoeck, H-W, Berneman, ZN, Van Tendeloo, VFI, Nijs, G, Lenjou, M, Henckaerts, E, Boeckxtaens, CJ, Vandenabeele, P, Kestens, LL, Van Bockstaele, DR, Vanham, GLEE.
Generation of dendritic cells from bone marrow progenitors using GM-CSF, TNF-a, and additional cytokines: Antagonistic effects of IL-4 and IFN-g and selective involvement of TNF-a receptor-1
Immunology 91, 553-559, 1997. (Epub ---)

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