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Van de Craen, M, Berx, G, Van den brande, I, Fiers, W, Declercq, W, Vandenabeele, P.
Proteolytic cleavage of beta-catenin by caspases: An in vitro analysis
FEBS Lett 458, 167-170, 1999. (Epub ---)

Van de Craen, M, Declercq, W, Van den brande, I, Fiers, W, Vandenabeele, P.
The proteolytic procaspase activation network: An in vitro analysis
Cell Death Differ 6, 1117-1124, 1999. (Epub ---)

Van de Craen, M, De Jonghe, C, Van den brande, I, Declercq, W, Van Gassen, G, Van Criekinge, W, Vanderhoeven, I, Fiers, W, Van Broeckhoven, C, Hendriks, L, Vandenabeele, P.
Identification of caspases that cleave presenilin-1 and presenilin-2. Five presenilin-1 (PS1) mutations do not alter the sensitivity of PS1 to caspases
FEBS Lett 445, 149-154, 1999. (Epub ---)

Van Molle, W, Denecker, G, Rodriguez, I, Brouckaert, P, Vandenabeele, P, Libert, C.
Activation of caspases in lethal experimental hepatitis and prevention by acute phase proteins
J Immunol 163, 5235-5241, 1999. (Epub ---)

Declercq, W, Denecker, G, Fiers, W, Vandenabeele, P.
Cooperation of both TNF receptors in inducing apoptosis: Involvement of the TNF receptor-associated factor binding domain of the TNF receptor 75
J Immunol 161, 390-399, 1998. (Epub ---)

De Vos, K, Goossens, V, Boone, E, Vercammen, D, Vancompernolle, K, Vandenabeele, P, Haegeman, G, Fiers, W, Grooten, J.
The 55-kDa tumor necrosis factor receptor induces clustering of mitochondria through its membrane-proximal region
J Biol Chem 273, 9673-9680, 1998. (Epub ---)

Penning, LC, Schipper, RG, Vercammen, D, Verhofstad, AAJ, Denecker, T, Beyaert, R, Vandenabeele, P.
Sensitization of TNF-induced apoptosis with polyamine synthesis inhibitors in different human and murine tumour cell lines
Cytokine 10, 423-431, 1998. (Epub ---)

Prins, JB, Ledgerwood, EC, Ameloot, P, Vandenabeele, P, Faraco, PR, Bright, NA, O'Rahilly, S, Bradley, JR.
Tumor necrosis factor-induced cytotoxicity is not related to rates of mitochondrial morphological abnormalities or autophagy-changes that can be mediated by TNFR-I or TNFR-II
Biosci Rep 18, 329-340, 1998. (Epub ---)

Schotte, P, Van Criekinge, W, Van de Craen, M, van Loo, G, Desmedt, M, Grooten, J, Cornelissen, M, De Ridder, L, Vandekerckhove, J, Fiers, W, Vandenabeele, P, Beyaert, R.
Cathepsin B-mediated activation of the proinflammatory caspase-11
Biochem Biophys Res Commun 251, 379-387, 1998. (Epub ---)

Steemans, M, Goossens, V, Van de Craen, M, Van Herreweghe, F, Vancompernolle, K, De Vos, K, Vandenabeele, P, Grooten, J.
A caspase-activated factor (CAF) induces mitochondrial membrane depolarization and cytochrome c release by a nonproteolytic mechanism
J Exp Med 188, 2193-2198, 1998. (Epub ---)

Vancompernolle, K, Van Herreweghe, F, Pynaert, G, Van de Craen, M, De Vos, K, Totty, N, Sterling, A, Fiers, W, Vandenabeele, P, Grooten, J.
Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity
FEBS Lett 438, 150-158, 1998. (Epub ---)

Van Criekinge, W, van Gurp, M, Decoster, E, Schotte, P, Van de Craen, M, Fiers, W, Vandenabeele, P, Beyaert, R.
Use of the yeast three-hybrid system as a tool to study caspases
Anal Biochem 263, 62-66, 1998. (Epub ---)

Van de Craen, M, van Loo, G, Pype, S, Van Criekinge, W, Van den brande, I, Molemans, F, Fiers, W, Declercq, W, Vandenabeele, P.
Identification of a new caspase homologue: Caspase-14
Cell Death Differ 5, 838-846, 1998. (Epub ---)

Van de Craen, M, van Loo, G, Van den brande, I, Declercq, W, Mandruzzato, S, van der Bruggen, P, Fiers, W, Vandenabeele, P.
Molecular cloning and identification of murine caspase-8
J Mol Biol 284, 1017-1026, 1998. (Epub ---)

Vantieghem, A, Assefa, Z, Vandenabeele, P, Declercq, W, Courtois, S, Vandenheede, JR, Merlevede, W, de Witte, P, Agostinis, P.
Hypericin-induced photosensitization of HeLa cells leads to apoptosis or necrosis. Involvement of cytochrome c and procaspase-3 activation in the mechanism of apoptosis
FEBS Lett 440, 19-24, 1998. (Epub ---)

Vercammen, D, Beyaert, R, Denecker, G, Goossens, V, van Loo, G, Declercq, W, Grooten, J, Fiers, W, Vandenabeele, P.
Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor
J Exp Med 187, 1477-1485, 1998. (Epub ---)

Vercammen, D, Brouckaert, G, Denecker, G, Van de Craen, M, Declercq, W, Fiers, W, Vandenabeele, P.
Dual signaling of the Fas receptor: Initiation of both apoptotic and necrotic cell death pathways
J Exp Med 188, 919-930, 1998. (Epub ---)

Barge, RMY, Willemze, R, Vandenabeele, P, Fiers, W, Beyaert, R.
Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth withdrawal
FEBS Lett 409, 207-210, 1997. (Epub ---)

Beyaert, R, Kidd, VJ, Cornelis, S, Van de Craen, M, Denecker, G, Lahti, JM, Gururajan, R, Vandenabeele, P, Fiers, W.
Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor
J Biol Chem 272, 11694-11697, 1997. (Epub ---)

Denecker, G, Vandenabeele, P, Grooten, J, Penning, LC, Declercq, W, Beyaert, R, Buurman, WA, Fiers, W.
Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma
Cytokine 9, 631-638, 1997. (Epub ---)

Dentener, MA, Francot, GJM, Hiemstra, PS, Tool, ATJ, Verhoeven, AJ, Vandenabeele, P, Buurman, WA.
Bactericidal/permeability-increasing protein release in whole blood ex vivo: Strong induction by lipopolysaccharide and tumor necrosis factor-alpha
J Infect Dis 175, 108-117, 1997. (Epub ---)

De Valck, D, Heyninck, K, Van Criekinge, W, Vandenabeele, P, Fiers, W, Beyaert, R.
A20 inhibits NF-kB activation independently of binding to 14-3-3 proteins
Biochem Biophys Res Commun 238, 590-594, 1997. (Epub ---)

Fiers, W, Beyaert, R, Boone, E, Declercq, W, Decoster, E, De Valck, D, Goossens, V, Grooten, J, Haegeman, G, Heyninck, K, Penning, L, Plaisance, S, Van de Craen, M, Vandenabeele, P, Vanden Berghe, W, Vandevoorde, V, Vercammen, D.
Tumour necrosis factor: Intracellular mechanism of action
In HIV and Cytokines. (Guenounou, M, ed.), Paris, INSERM, pp. 33-41 , 1997. (Epub ---)

Lardon, F, Snoeck, H-W, Berneman, ZN, Van Tendeloo, VFI, Nijs, G, Lenjou, M, Henckaerts, E, Boeckxtaens, CJ, Vandenabeele, P, Kestens, LL, Van Bockstaele, DR, Vanham, GLEE.
Generation of dendritic cells from bone marrow progenitors using GM-CSF, TNF-a, and additional cytokines: Antagonistic effects of IL-4 and IFN-g and selective involvement of TNF-a receptor-1
Immunology 91, 553-559, 1997. (Epub ---)

Van de Craen, M, Vandenabeele, P, Declercq, W, Van den brande, I, van Loo, G, Molemans, F, Schotte, P, Van Criekinge, W, Beyaert, R, Fiers, W.
Characterization of seven murine caspase family members
FEBS Lett 403, 61-69, 1997. (Epub ---)

Van de Craen, M, Van den brande, I, Declercq, W, Irmler, M, Beyaert, R, Tschopp, J, Fiers, W, Vandenabeele, P.
Cleavage of caspase family members by granzyme B: A comparative study in vitro
Eur J Immunol 27, 1296-1299, 1997. (Epub ---)

Vercammen, D, Vandenabeele, P, Beyaert, R, Declercq, W, Fiers, W.
Tumour necrosis factor-induced necrosis versus anti-Fas-induced apoptosis in L929 cells
Cytokine 9, 801-808, 1997. (Epub ---)

Wallach, D, Boldin, M, Varfolomeev, E, Beyaert, R, Vandenabeele, P, Fiers, W.
Cell death induction by receptors of the TNF family: Towards a molecular understanding
FEBS Lett 410, 96-106, 1997. (Epub ---)

Benigni, F, Faggioni, R, Sironi, M, Fantuzzi, G, Vandenabeele, P, Takahashi, N, Sacco, S, Fiers, W, Buurman, WA, Ghezzi, P.
TNF receptor p55 plays a major role in centrally mediated increases of serum IL-6 and corticosterone after intracerebroventricular injection of TNF
J Immunol 157, 5563-5568, 1996. (Epub ---)

Fiers, W, Beyaert, R, Boone, E, Cornelis, S, Declercq, W, Decoster, E, Denecker, G, Depuydt, B, De Valck, D, De Wilde, G, Goossens, V, Grooten, J, Haegeman, G, Heyninck, K, Penning, L, Plaisance, S, Vancompernolle, K, Van Criekinge, W, Vandenabeele, P, et al..
TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis
J Inflamm 47, 67-75, 1996. (Epub ---)

Marchant, A, Amraoui, Z, Gueydan, C, Bruyns, C, Le Moine, O, Vandenabeele, P, Fiers, W, Buurman, WA, Goldman, M.
Methylprednisolone differentially regulates interleukin-10 and tumor necrosis factor production during murine endotoxemia
Clin Exp Immunol 106, 91-96, 1996. (Epub ---)

Van Criekinge, W, Beyaert, R, Van de Craen, M, Vandenabeele, P, Schotte, P, De Valck, D, Fiers, W.
Functional characterization of the prodomain of interleukin-1b-converting enzyme
J Biol Chem 271, 27245-27248, 1996. (Epub ---)

Beyaert, R, Vanhaesebroeck, B, Declercq, W, Van Lint, J, Vandenabeele, P, Agostinis, P, Vandenheede, JR, Fiers, W.
Casein kinase-1 phosphorylates the p75 tumor necrosis factor receptor and negatively regulates tumor necrosis factor signaling for apoptosis
J Biol Chem 270, 23293-23299, 1995. (Epub ---)

Declercq, W, Vandenabeele, P, Fiers, W.
Dimerization of chimeric erythropoietin/75 kDa tumour necrosis factor (TNF) receptors transduces TNF signals: Necessity for the 75 kDa-TNF receptor transmembrane domain
Cytokine 7, 701-709, 1995. (Epub ---)

Decoster, E, Vanhaesebroeck, B, Vandenabeele, P, Grooten, J, Fiers, W.
Generation and biological characterization of membrane-bound, uncleavable murine tumor necrosis factor
J Biol Chem 270, 18473-18478, 1995. (Epub ---)

Vandenabeele, P, Declercq, W, Beyaert, R, Fiers, W.
Two tumour necrosis factor receptors: Structure and function
Trends Cell Biol 5, 392-399, 1995. (Epub ---)

Vandenabeele, P, Declercq, W, Vanhaesebroeck, B, Grooten, J, Fiers, W.
Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells
J Immunol 154, 2904-2913, 1995. (Epub ---)

Vercammen, D, Vandenabeele, P, Declercq, W, Van de Craen, M, Grooten, J, Fiers, W.
Cytotoxicity in L929 murine fibrosarcoma cells after triggering of transfected human p75 tumour necrosis factor (TNF) receptor is mediated by endogenous murine TNF
Cytokine 7, 463-470, 1995. (Epub ---)

Barbara, JAJ, Smith, WB, Gamble, JR, Van Ostade, X, Vandenabeele, P, Tavernier, J, Fiers, W, Vadas, MA, Lopez, AF.
Dissociation of TNF-a cytotoxic and proinflammatory activities by p55 receptor- and p75 receptor-selective TNF-a mutants
EMBO J 13, 843-850, 1994. (Epub ---)

Donckier, V, Abramowicz, D, Bruyns, C, Florquin, S, Vanderhaegen, M-L, Amraoui, Z, Dubois, C, Vandenabeele, P, Goldman, M.
IFN-g prevents Th2 cell-mediated pathology after neonatal injection of semiallogenic spleen cells in mice
J Immunol 153, 2361-2368, 1994. (Epub ---)

Donckier, V, Flament, V, Gérard, C, Abramowicz, D, Vandenabeele, P, Wissing, M, Delvaux, A, Fiers, W, Leo, O, Velu, T, Goldman, M.
Modulation of the release of cytokines and reduction of the shock syndrome induced by anti-CD3 monoclonal antibody in mice by interleukin-10
Transplantation 57, 1436-1439, 1994. (Epub ---)

Flamand, V, Donckier, V, Abramowicz, D, Goldman, M, Vandenabeele, P, Urbain, J, Moser, M, Leo, O.
In vivo immunosuppression induced by a weakly mitogenic antibody to mouse CD3: Evidence that induction of long-lasting in vivo unresponsiveness requires TcR signaling
Cell Immunol 157, 239-248, 1994. (Epub ---)

Marchant, A, Bruyns, C, Vandenabeele, P, Abramowicz, D, Gérard, C, Delvaux, A, Ghezzi, P, Velu, T, Goldman, M.
The protective role of interleukin-10 in endotoxin shock
Prog Clin Biol Res 388, 417-423, 1994. (Epub ---)

Marchant, A, Bruyns, C, Vandenabeele, P, Ducarme, M, Gérard, C, Delvaux, A, De Groote, D, Abramowicz, D, Velu, T, Goldman, M.
Interleukin-10 controls interferon-gamma and tumor necrosis factor production during experimental endotoxemia
Eur J Immunol 24, 1167-1171, 1994. (Epub ---)

Vandenabeele, P, Goossens, V, Beyaert, R, Declercq, W, Grooten, J, Vanhaesebroeck, B, Van de Craen, M, Vercammen, D, Depuydt, B, Denecker, G, Fiers, W.
Functional requirement of the two TNF receptors for induction of apoptosis in PC60 cells and the role of mitochondria in TNF-induced cytotoxicity
Circ Shock 44, 196-200, 1994. (Epub ---)

Van Ostade, X, Vandenabeele, P, Tavernier, J, Fiers, W.
Human tumor necrosis factor mutants with preferential binding to and activity on either the R55 or R75 receptor
Eur J Biochem 220, 771-779, 1994. (Epub ---)

Fiers, W, Beyaert, R, Brouckaert, P, Cauwels, A, Declercq, W, De Valck, D, Everaerdt, B, Goossens, V, Grooten, J, Haegeman, G, Libert, C, Schulze-Osthoff, K, Takahashi, N, Vandenabeele, P, Vanhaesebroeck, B, Van Ostade, X, Van Roy, F.
Two pathways of tumor necrosis factor signal transduction: In vitro and in vivo implications
In Tumor Necrosis Factor: Molecular and Cellular Biology and Clinical Relevance. (Fiers, W, Buurman, WA, eds.), Basel, Karger (Shugar, D, Rode, W, Borowski, E, eds.), Warszawa-Berlin, Polish Scientific Publishers PWN/Springer-Verlag, pp. 58-65, 1993. (Epub ---)

Gérard, C, Bruyns, C, Marchant, A, Abramowicz, D, Vandenabeele, P, Delvaux, A, Fiers, W, Goldman, M, Velu, T.
Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia
J Exp Med 177, 547-550, 1993. (Epub ---)

Vandenabeele, P, Abramowicz, D, Berus, D, Van der Heyden, J, Grooten, J, Donckier, V, Hooghe-Peters, EL, Goldman, M, Fiers, W.
Increased IL-6 production and IL-6-mediated Ig secretion in murine host-vs-graft disease
J Immunol 150, 4179-4187, 1993. (Epub ---)

Van Ostade, X, Vandenabeele, P, Everaerdt, B, Loetscher, H, Gentz, R, Brockhaus, M, Lesslauer, W, Tavernier, J, Brouckaert, P, Fiers, W.
Human TNF mutants with selective activity on the p55 receptor
Nature 361, 266-269, 1993. (Epub ---)

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