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Publications from this research unit

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Lamkanfi, M, Declercq, W, Kalai, M, Saelens, X, Vandenabeele, P.
Alice in caspase land. A phylogenetic analysis of caspases from worm to man
Cell Death Differ 9, 358-361, 2002. (Epub ---)

McFarlane, SM, Pashmi, G, Connell, MC, Littlejohn, AF, Tucker, SJ, Vandenabeele, P, MacEwan, DJ.
Differential activation of nuclear factor-kB by tumour necrosis factor receptor subtypes. TNFR1 predominates whereas TNFR2 activates transcription poorly
FEBS Lett 515, 119-126, 2002. (Epub ---)

Mohamed, AAA, Jupp, OJ, Anderson, HM, Littlejohn, AF, Vandenabeele, P, MacEwan, DJ.
Tumour necrosis factor-induced activation of c-Jun N-terminal kinase is sensitive to caspase-dependent modulation while activation of mitogen-activated protein kinase (MAPK) or p38 MAPK is not
Biochem J 366, 145-155, 2002. (Epub ---)

Pollock, J, McFarlane, SM, Connell, MC, Zehavi, U, Vandenabeele, P, MacEwan, DJ, Scott, RH.
TNF-a receptors simultaneously activate Ca2+ mobilisation and stress kinases in cultured sensory neurones
Neuropharmacology 42, 93-106, 2002. (Epub ---)

Rendl, M, Ban, J, Mrass, P, Mayer, C, Lengauer, B, Eckhart, L, Declercq, W, Tschachler, E.
Caspase-14 expression by epidermal keratinocytes is regulated by retinoids in a differentiation-associated manner
J Invest Dermatol 119, 1150-1155, 2002. (Epub ---)

Storey, H, Stewart, A, Vandenabeele, P, Luzio, JP.
The p55 tumour necrosis factor receptor TNFR1 contains a trans-Golgi network localization signal in the C-terminal region of its cytoplasmic tail
Biochem J 366, 15-22, 2002. (Epub ---)

van Loo, G, Demol, H, van Gurp, M, Hoorelbeke, B, Schotte, P, Beyaert, R, Zhivotovsky, B, Gevaert, K, Declercq, W, Vandekerckhove, J, Vandenabeele, P.
A matrix-assisted laser desorption ionization post-source decay (MALDI-PSD) analysis of proteins released from isolated liver mitochondria treated with recombinant truncated Bid
Cell Death Differ 9, 301-308, 2002. (Epub ---)

van Loo, G, Saelens, X, Matthijssens, F, Schotte, P, Beyaert, R, Declercq, W, Vandenabeele, P.
Caspases are not localized in mitochondria during life or death
Cell Death Differ 9, 1207-1211, 2002. (Epub ---)

van Loo, G, Saelens, X, van Gurp, M, MacFarlane, M, Martin, SJ, Vandenabeele, P.
The role of mitochondrial factors in apoptosis: A Russian roulette with more than one bullet
Cell Death Differ 9, 1031-1042, 2002. (Epub ---)

van Loo, G, van Gurp, M, Depuydt, B, Srinivasula, SM, Rodriguez, I, Alnemri, ES, Gevaert, K, Vandekerckhove, J, Declercq, W, Vandenabeele, P.
The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity
Cell Death Differ 9, 20-26, 2002. (Epub ---)

Varghese, J, Sade, H, Vandenabeele, P, Sarin, A.
Head involution defective (Hid)-triggered apoptosis requires caspase-8 but not FADD (Fas-associated death domain) and is regulated by Erk in mammalian cells
J Biol Chem 277, 35097–35104, 2002. (Epub 2002 Jul 16)

Ameloot, P, Declercq, W, Fiers, W, Vandenabeele, P, Brouckaert, P.
Heterotrimers formed by tumor necrosis factors of different species or muteins
J Biol Chem 276, 27098-27103, 2001. (Epub 2001 May 22)

Ameloot, P, Fiers, W, De Bleser, P, Ware, CF, Vandenabeele, P, Brouckaert, P.
Identification of tumor necrosis factor (TNF) amino acids crucial for binding to the murine p75 TNF receptor and construction of receptor-selective mutants
J Biol Chem 276, 37426-37430, 2001. (Epub 2001 Jul 11)

Daemen, MARC, Denecker, G, van 't Veer, C, Wolfs, TGAM, Vandenabeele, P, Buurman, WA.
Activated caspase-1 is not a central mediator of inflammation in the course of ischemia-reperfusion
Transplantation 71, 778-784, 2001. (Epub ---)

Denecker, G, Declercq, W, Geuijen, CAW, Boland, A, Benabdillah, R, van Gurp, M, Sory, M-P, Vandenabeele, P, Cornelis, GR.
Yersinia enterocolitica YopP-induced apoptosis of macrophages involves the apoptotic signaling cascade upstream of Bid
J Biol Chem 276, 19706-19714, 2001. (Epub 2001 Mar 14)

Denecker, G, Vercammen, D, Declercq, W, Vandenabeele, P.
Apoptotic and necrotic cell death induced by death domain receptors
Cell Mol Life Sci 58, 356-370, 2001. (Epub ---)

Denecker, G, Vercammen, D, Steemans, M, Vanden Berghe, T, Brouckaert, G, van Loo, G, Zhivotovsky, B, Fiers, W, Grooten, J, Declercq, W, Vandenabeele, P.
Death receptor-induced apoptotic and necrotic cell death: Differential role of caspases and mitochondria
Cell Death Differ 8, 829-840, 2001. (Epub ---)

Frame, M, Wan, KF, Tate, R, Vandenabeele, P, Pyne, NJ.
The g subunit of the rod photoreceptor cGMP phosphodiesterase can modulate the proteolysis of two cGMP binding cGMP-specific phosphodiesterases (PDE6 and PDE5) by caspase-3
Cell Signal 13, 735-741, 2001. (Epub ---)

Jupp, OJ, McFarlane, SM, Anderson, HM, Littlejohn, AF, Mohamed, AAA, MacKay, RH, Vandenabeele, P, MacEwan, DJ.
Type II tumour necrosis factor-alpha receptor (TNFR2) activates c-Jun N-terminal kinase (JNK) but not mitogen-activated protein kinase (MAPK) or p38 MAPK pathways
Biochem J 359, 525-535, 2001. (Epub ---)

Marti, A, Ritter, PM, Jäger, R, Lazar, H, Baltzer, A, Schenkel, J, Declercq, W, Vandenabeele, P, Jaggi, R.
Mouse mammary gland involution is associated with cytochrome c release and caspase activation
Mech Dev 104, 89-98, 2001. (Epub ---)

McFarlane, SM, Jupp, OJ, Cobban, HJ, Hunter, I, Anderson, HM, Vandenabeele, P, Nixon, GF, MacEwan, DJ.
Stimulation of stress-activated but not mitogen-activated protein kinases by tumour necrosis factor receptor subtypes in airway smooth muscle
Biochem Pharmacol 61, 749-759, 2001. (Epub ---)

Saelens, X, Kalai, M, Vandenabeele, P.
Translation inhibition in apoptosis. Caspase-dependent PKR activation and eIF2-a phosphorylation
J Biol Chem 276, 41620-41628, 2001. (Epub 2001 Sep 12)

Schotte, P, van Loo, G, Carpentier, I, Vandenabeele, P, Beyaert, R.
Lithium sensitizes tumor cells in an NF-kB-independent way to caspase activation and apoptosis induced by tumor necrosis factor (TNF). Evidence for a role of the TNF receptor-associated death domain protein
J Biol Chem 276, 25939-25945, 2001. (Epub 2001 May 7)

Shalak, V, Kaminska, M, Mitnacht-Kraus, R, Vandenabeele, P, Clauss, M, Mirande, M.
The EMAPII cytokine is released from the mammalian multisynthetase complex after cleavage of its p43/proEMAPII component
J Biol Chem 276, 23769-23776, 2001. (Epub 2001 Apr 16)

Vanderheyde, N, Aksoy, E, Amraoui, Z, Vandenabeele, P, Goldman, M, Willems, F.
Tumoricidal activity of monocyte-derived dendritic cells: Evidence for a caspase-8-dependent, Fas-associated death domain-independent mechanism
J Immunol 167, 3565-3569, 2001. (Epub ---)

van Loo, G, Schotte, P, van Gurp, M, Demol, H, Hoorelbeke, B, Gevaert, K, Rodriguez, I, Ruiz-Carrillo, A, Vandekerckhove, J, Declercq, W, Beyaert, R, Vandenabeele, P.
Endonuclease G: A mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation
Cell Death Differ 8, 1136-1142, 2001. (Epub ---)

Vantieghem, A, Xu, Y, Declercq, W, Vandenabeele, P, Denecker, G, Vandenheede, JR, Merlevede, W, de Witte, PA, Agostinis, P.
Different pathways mediate cytochrome c release after photodynamic therapy with hypericin
Photochem Photobiol 74, 133-142, 2001. (Epub ---)

Vántus, T, Kéri, G, Krivickiene, Z, Valius, M, Steták, A, Keppens, S, Csermely, P, Bauer, PI, Bökönyi, G, Declercq, W, Vandenabeele, P, Merlevede, W, Vandenheede, JR.
The somatostatin analogue TT-232 induces apoptosis in A431 cells. Sustained activation of stress-activated kinases and inhibition of signalling to extracellular signal-regulated kinases
Cell Signal 13, 717-725, 2001. (Epub ---)

Assefa, Z, Vantieghem, A, Garmyn, M, Declercq, W, Vandenabeele, P, Vandenheede, JR, Bouillon, R, Merlevede, W, Agostinis, P.
p38 Mitogen-activated protein kinase regulates a novel, caspase-independent pathway for the mitochondrial cytochrome c release in ultraviolet B radiation-induced apoptosis
J Biol Chem 275, 21416-21421, 2000. (Epub ---)

Behrensdorf, HA, Van de Craen, M, Knies, UE, Vandenabeele, P, Clauss, M.
The endothelial monocyte-activating polypeptide II (EMAP II) is a substrate for caspase-7
FEBS Lett 466, 143-147, 2000. (Epub ---)

Boone, E, Vanden Berghe, T, van Loo, G, De Wilde, G, De Wael, N, Vercammen, D, Fiers, W, Haegeman, G, Vandenabeele, P.
Structure/function analysis of p55 tumor necrosis factor receptor and Fas-associated death domain. Effect on necrosis in L929sA cells
J Biol Chem 275, 37596-37603, 2000. (Epub ---)

Daemen, MARC, Heemskerk, VH, van 't Veer, C, Denecker, G, Wolfs, TGAM, Vandenabeele, P, Buurman, WA.
Functional protection by acute phase proteins a1-acid glycoprotein and a1-antitrypsin against ischemia/reperfusion injury by preventing apoptosis and inflammation
Circulation 102, 1420-1426, 2000. (Epub ---)

Daemen, MARC, Vandenabeele, P, Buurman, WA.
How cells die counts
Am J Kidney Dis 36, 665-668, 2000. (Epub ---)

Declercq, W, Logghe, M, Fiers, W, Contreras, R.
Cloning and expression of cytokine genes
In Cytokine Molecular Biology A Practical Approach. (Balkwill, F, ed.), Oxford, University Press, pp. 1-20, 2000. (Epub ---)

Denecker, G, Dooms, H, van Loo, G, Vercammen, D, Grooten, J, Fiers, W, Declercq, W, Vandenabeele, P.
Phosphatidyl serine exposure during apoptosis precedes release of cytochrome c and decrease in mitochondrial transmembrane potential
FEBS Lett 465, 47-52, 2000. (Epub ---)

Eckhart, L, Declercq, W, Ban, J, Rendl, M, Lengauer, B, Mayer, C, Lippens, S, Vandenabeele, P, Tschachler, E.
Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation
J Invest Dermatol 115, 1148-1151, 2000. (Epub ---)

Goossens, V, De Vos, K, Vercammen, D, Steemans, M, Vancompernolle, K, Fiers, W, Vandenabeele, P, Grooten, J.
Role of reactive oxygen species in tumor necrosis factor toxicity
In Antioxidant and Redox Regulation of Genes. (Sen, CK, Sies, H, Baeuerle, PA, eds.), San Diego, Academic Press, pp. 245-264 , 2000. (Epub ---)

Huston, E, Beard, M, McCallum, F, Pyne, NJ, Vandenabeele, P, Scotland, G, Houslay, MD.
The cAMP-specific phosphodiesterase PDE4A5 is cleaved downstream of its SH3 interaction domain by caspase-3. Consequences for altered intracellular distribution
J Biol Chem 275, 28063-28074, 2000. (Epub ---)

Lippens, S, Kockx, M, Knaapen, M, Mortier, L, Polakowska, R, Verheyen, A, Garmyn, M, Zwijsen, A, Formstecher, P, Huylebroeck, D, Vandenabeele, P, Declercq, W.
Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing
Cell Death Differ 7, 1218-1224, 2000. (Epub ---)

Penning, L, Denecker, G, Vercammen, D, Declercq, W, Schipper, RG, Vandenabeele, P.
A role for potassium in TNF-induced apoptosis and gene-induction in human and rodent tumour cell lines
Cytokine 12, 747-750, 2000. (Epub ---)

Pype, S, Declercq, W, Ibrahimi, A, Michiels, C, Van Rietschoten, JGL, Dewulf, N, de Boer, M, Vandenabeele, P, Huylebroeck, D, Remacle, JE.
TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kB activation
J Biol Chem 275, 18586-18593, 2000. (Epub ---)

Assefa, Z, Vantieghem, A, Declercq, W, Vandenabeele, P, Vandenheede, JR, Merlevede, W, de Witte, P, Agostinis, P.
The activation of the c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signaling pathways protects HeLa cells from apoptosis following photodynamic therapy with hypericin
J Biol Chem 274, 8788-8796, 1999. (Epub ---)

Baxter, GT, Kuo, RC, Jupp, OJ, Vandenabeele, P, MacEwan, DJ.
Tumor necrosis factor-alpha mediates both apoptotic cell death and cell proliferation in a human hematopoietic cell line dependent on mitotic activity and receptor subtype expression
J Biol Chem 274, 9539-9547, 1999. (Epub ---)

Daemen, MARC, van 't Veer, C, Denecker, G, Heemskerk, VH, Wolfs, TGAM, Clauss, M, Vandenabeele, P, Buurman, WA.
Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation
J Clin Invest 104, 541-549, 1999. (Epub ---)

De Bleecker, JL, Meire, VI, Declercq, W, Van Aken, EH.
Immunolocalization of tumor necrosis factor-alpha and its receptors in inflammatory myopathies
Neuromusc Disorders 9, 239-246, 1999. (Epub ---)

Eymin, B, Sordet, O, Droin, N, Munsch, B, Haugg, M, Van de Craen, M, Vandenabeele, P, Solary, E.
Caspase-induced proteolysis of the cyclin-dependent kinase inhibitor p27Kip1 mediates its anti-apoptotic activity
Oncogene 18, 4839-4847, 1999. (Epub ---)

Faraco, PR, Ledgerwood, EC, Vandenabeele, P, Prins, JB, Bradley, JR.
Tumor necrosis factor induces distinct patterns of caspase activation in WEHI-164 cells associated with apoptosis or necrosis depending on cell cycle stage
Biochem Biophys Res Commun 261, 385-392, 1999. (Epub ---)

Ferrari, D, Los, M, Bauer, MKA, Vandenabeele, P, Wesselborg, S, Schulze-Osthoff, K.
P2Z purinoreceptor ligation induces activation of caspases with distinct roles in apoptotic and necrotic alterations of cell death
FEBS Lett 447, 71-75, 1999. (Epub ---)

Fiers, W, Beyaert, R, Declercq, W, Vandenabeele, P.
More than one way to die: Apoptosis, necrosis and reactive oxygen damage
Oncogene 18, 7719-7730, 1999. (Epub ---)

Goossens, V, De Vos, K, Vercammen, D, Steemans, M, Vancompernolle, K, Fiers, W, Vandenabeele, P, Grooten, J.
Redox regulation of TNF signaling
BioFactors 10, 145-156, 1999. (Epub ---)

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