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Publications from this research unit

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de Haan, W, Dheedene, W, Apelt, K, Decombas-Deschamps, S, Vinckier, S, Verhulst, S, Conidi, A, Deffieux, T, Staring, MW, Vandervoort, P, Caluwe, E, Lox, M, Mannaerts, I, Takagi, T, Jaekers, J, Berx, G, Haigh, J, Topal, B, Zwijsen, A, et al..
Endothelial Zeb2 preserves the hepatic angioarchitecture and protects against liver fibrosis
Cardiovasc Res , in press, 2021. (Epub 2021 Apr 28)

Jonckheere, S, Adams, J, De Groote, D, Campbell, K, Berx, G, Goossens, S.
Epithelial-Mesenchymal Transition (EMT) as a Therapeutic Target
Cells Tissues Organs , 1-26, 2021. (Epub 2021 Jan 5)

Lasierra Losada, M, Pauler, M, Vandamme, N, Goossens, S, Berx, G, Leppkes, M, Schuhwerk, H, Brabletz, S, Brabletz, T, Stemmler, MP.
Pancreas morphogenesis and homeostasis depends on tightly regulated Zeb1 levels in epithelial cells
Cell Death Discov 7, 138, 2021. (Epub 2021 Jun 11)

Ruh, M, Stemmler, MP, Frisch, I, Fuchs, K, van Roey, R, Kleemann, J, Roas, M, Schuhwerk, H, Eccles, RL, Agaimy, A, Baumhoer, D, Berx, G, Muller, F, Brabletz, T, Brabletz, S.
The EMT transcription factor ZEB1 blocks osteoblastic differentiation in bone development and osteosarcoma
J Pathol 254, 199-211, 2021. (Epub 2021 Mar 5)

Sreekumar, R, Al-Saihati, H, Emaduddin, M, Moutasim, K, Mellone, M, Patel, A, Kilic, S, Cetin, M, Erdemir, S, Navio, MS, Lopez, MA, Curtis, N, Yagci, T, Primrose, JN, Price, BD, Berx, G, Thomas, GJ, Tulchinsky, E, Mirnezami, A, et al..
The ZEB2-dependent EMT transcriptional programme drives therapy resistance by activating nucleotide excision repair genes ERCC1 and ERCC4 in colorectal cancer
Mol Oncol , in press, 2021. (Epub 2021 May 1)

Wang, J, Farkas, C, Benyoucef, A, Carmichael, C, Haigh, K, Wong, N, Huylebroeck, D, Stemmler, MP, Brabletz, S, Brabletz, T, Nefzger, CM, Goossens, S, Berx, G, Polo, JM, Haigh, JJ.
Interplay between the EMT transcription factors ZEB1 and ZEB2 regulates hematopoietic stem and progenitor cell differentiation and hematopoietic lineage fidelity
PLoS Biol 19, e3001394, 2021. (Epub 2021 Sep 22)

Aaes, TL, Verschuere, H, Kaczmarek, A, Heyndrickx, L, Wiernicki, B, Delrue, I, De Craene, B, Taminau, J, Delvaeye, T, Bertrand, MJM, Declercq, W, Berx, G, Krysko, DV, Adjemian, S, Vandenabeele, P.
Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection
J Immunol 204, 775-787, 2020. (Epub 2020 Jan 3)

Bruneel, K, Verstappe, J, Vandamme, N, Berx, G.
Intrinsic Balance between ZEB Family Members Is Important for Melanocyte Homeostasis and Melanoma Progression
Cancers (Basel) 12, 2248, 2020. (Epub 2020 Aug 11)

Carmichael, CL, Wang, J, Nguyen, T, Kolawole, O, Benyoucef, A, De Maziere, C, Milne, A, Samuel, S, Gillinder, KR, Hediyeh-Zadeh, S, Vo, ANQ, Huang, Y, Knezevic, K, McInnes, WRL, Shields, BJ, Mitchell, H, Ritchie, ME, Lammens, T, Lintermans, B, et al..
The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1
Blood 136, 957-973, 2020. (Epub 2020 May 5)

De Thaye, E, Van de Vijver, K, Van der Meulen, J, Taminau, J, Wagemans, G, Denys, H, Van Dorpe, J, Berx, G, Ceelen, W, Van Bocxlaer, J, De Wever, O.
Establishment and characterization of a cell line and patient-derived xenograft (PDX) from peritoneal metastasis of low-grade serous ovarian carcinoma
Sci Rep 10, 6688, 2020. (Epub 2020 Apr 21)

Picard, M, Yonekura, S, Slowicka, K, Petta, I, Rauber, C, Routy, B, Richard, C, Iebba, V, Tidjani Alou, M, Becharef, S, Ly, P, Pizzato, E, Lehmann, CHK, Amon, L, Klein, C, Opolon, P, Gomperts Boneca, I, Scoazec, JY, Hollebecque, A, et al..
Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients
Cell Death Differ , in press, 2020. (Epub 2020 Dec 1)

Slowicka, K, Petta, I, Blancke, G, Hoste, E, Dumas, E, Sze, M, Vikkula, H, Radaelli, E, Haigh, J, Jonckheere, S, Taminau, J, Vandamme, N, Wullaert, A, Tulchinsky, E, Nittner, D, Van Vlierberghe, P, De Hertogh, G, Baldin, P, Etlioglu, E, et al. Berx, G, Vereecke, L, van Loo,G.
Zeb2 drives invasive and microbiota-dependent colon carcinoma
Nature Cancer 1, 620-634, 2020. (Epub 2020 Jun 15)

Vandamme, N, Denecker, G, Bruneel, K, Blancke, G, Akay, O, Taminau, J, De Coninck, J, De Smedt, E, Skrypek, N, Van Loocke, W, et al.,Nittner, D, Kohler, C, et al.,Bouchez, L, et al, Andries, V, Rambow, F, Van Vlierberghe, P, Goossens, S, van den Oord, J, Marine, J-C, Berx, G
The EMT transcription factor ZEB2 promotes proliferation of primary and metastatic melanoma while suppressing an invasive, mesenchymal-like phenotype
Cancer Res 80, 2983-2995, 2020. (Epub 2020 Jun 5)

Yang, J, Antin, P, Berx, G, Blanpain, C, Brabletz, T, Bronner, M, Campbell, K, Cano, A, Casanova, J, Christofori, G, Dedhar, S, Derynck, R, Ford, HL, Fuxe, J, Garcia de Herreros, A, Goodall, GJ, Hadjantonakis, AK, Huang, RJY, Kalcheim, C, et al..
Guidelines and definitions for research on epithelial-mesenchymal transition
Nat Rev Mol Cell Biol 21, 341-352, 2020. (Epub 2020 Apr 16)

Andries, V, De Keuckelaere, E, Staes, K, Hochepied, T, Taminau, J, Lemeire, K, Birembaut, P, Berx, G, van Roy, F.
A new mouse model to study the role of ectopic Nanos3 expression in cancer
BMC Cancer 19, 598, 2019. (Epub 2019 Jun 17)

De Coninck, S, Berx, G, Taghon, T, Van Vlierberghe, P, Goossens, S.
ZEB2 in T-cells and T-ALL
Adv Biol Regul 74, 100639, 2019. (Epub 2019 Jul 27)

Doornaert, M, De Maere, E, Colle, J, Declercq, H, Taminau, J, Lemeire, K, Berx, G, Blondeel, P.
Xenogen-free isolation and culture of human adipose mesenchymal stem cells
Stem Cell Res 40, 101532, 2019. (Epub 2019 Aug 8)

Doornaert, M, Depypere, B, Creytens, D, Declercq, H, Taminau, J, Lemeire, K, Monstrey, S, Berx, G, Blondeel, P.
Human decellularized dermal matrix seeded with adipose-derived stem cells enhances wound healing in a murine model: Experimental study
Ann Med Surg (Lond) 46, 4-11, 2019. (Epub 2019 Aug 7)

Goossens, S, Wang, J, Tremblay, C, De Medts, J, T'Sas, S, Nguyen, T, Saw, J, Haigh, K, Curtis, DJ, Van Vlierberghe, P, Berx, G, Taghon, T, Haigh, JJ.
ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms
Haematologica 104, 1608-1616, 2019. (Epub 2019 Jan 24)

Haensel, D, Sun, P, MacLean, AL, Ma, X, Zhou, Y, Stemmler, MP, Brabletz, S, Berx, G, Plikus, MV, Nie, Q, Brabletz, T, Dai, X.
An Ovol2-Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation
EMBO Rep 20, e46273, 2019. (Epub 2018 Nov 9)

Jin, Q, Martinez, CA, Arcipowski, KM, Zhu, Y, Gutierrez-Diaz, BT, Wang, KK, Johnson, MR, Volk, A, Wang, F, Wu, J, Grove, C, Wang, H, Sokirniy, I, Thomas, PM, Goo, YA, et al., Vandamme, N, Berx, G, Goossens, S, et al..
USP7 cooperates with NOTCH1 to drive the oncogenic transcriptional program in T cell leukemia
Clin Cancer Res 25, 222-239, 2019. (Epub 2018 Sep 17)

Loret, N, Denys, H, Tummers, P, Berx, G.
The Role of Epithelial-to-Mesenchymal Plasticity in Ovarian Cancer Progression and Therapy Resistance
Cancers (Basel) 11, , 2019. (Epub 2019 Jun 17)

Milani, G, Matthijssens, F, Van Loocke, W, Durinck, K, Roels, J, Peirs, S, Thenoz, M, Pieters, T, Reunes, L, Lintermans, B, Vandamme, N, Lammens, T, Van Roy, N, Van Nieuwerburgh, F, Deforce, D, Schwab, C, Raimondi, S, Dalla Pozza, L, Carroll, AJ, 3rd, et al..
Genetic characterization and therapeutic targeting of MYC-rearranged T cell acute lymphoblastic leukaemia
Br J Haematol 185, 169-174, 2019. (Epub 2018 Jun 25)

Pieters, T, T'Sas, S, Demoen, L, Almeida, A, Haenebalcke, L, Matthijssens, F, Lemeire, K, D'Hont, J, Van Rockeghem, F, Hochepied, T, Lintermans, B, Reunes, L, Lammens, T, Berx, G, Haigh, JJ, Goossens, S, Van Vlierberghe, P.
Novel strategy for rapid functional in vivo validation of oncogenic drivers in haematological malignancies
Sci Rep 9, 10577, 2019. (Epub 2019 Jul 22)

Punovuori, K, Migueles, RP, Malaguti, M, Blin, G, Macleod, KG, Carragher, NO, Pieters, T, van Roy, F, Stemmler, MP, Lowell, S.
N-cadherin stabilises neural identity by dampening anti-neural signals
Development 146, dev183269, 2019. (Epub 2019 Nov 8)

Vandamme, N, Berx, G.
From neural crest cells to melanocytes: cellular plasticity during development and beyond
Cell Mol Life Sci 76, 1919-1934, 2019. (Epub 2019 Mar 4)

Van Hove, H, Martens, L, Scheyltjens, I, De Vlaminck, K, Pombo Antunes, AR, De Prijck, S, Vandamme, N, De Schepper, S, Van Isterdael, G, Scott, CL, Aerts, J, Berx, G, Boeckxstaens, GE, Vandenbroucke, RE, Vereecke, L, Moechars, D, Guilliams, M, Van Ginderachter, JA, Saeys, Y, Movahedi, K.
A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment
Nat Neurosci 22, 10211035, 2019. (Epub 2019 May 6)

Bouhy, D, Juneja, M, Katona, I, Holmgren, A, Asselbergh, B, De Winter, V, Hochepied, T, Goossens, S, Haigh, JJ, Libert, C, Ceuterick-de Groote, C, Irobi, J, Weis, J, Timmerman, V.
A knock-in/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8
Acta Neuropathol 135, 131-148, 2018. (Epub 2017 Aug 5)

De Jaeghere, E, De Vlieghere, E, Van Hoorick, J, Van Vlierberghe, S, Wagemans, G, Pieters, L, Melsens, E, Praet, M, Van Dorpe, J, Boone, MN, Ghobeira, R, De Geyter, N, Bracke, M, Vanhove, C, Neyt, S, Berx, G, De Geest, BG, Dubruel, P, Declercq, H, et al..
Heterocellular 3D scaffolds as biomimetic to recapitulate the tumor microenvironment of peritoneal metastases in vitro and in vivo
Biomaterials 158, 95-105, 2018. (Epub 2017 Dec 23)

De Keuckelaere, E, Hulpiau, P, Saeys, Y, Berx, G, van Roy, F.
Nanos genes and their role in development and beyond
Cell Mol Life Sci 75, 1929-1946, 2018. (Epub 2018 Feb 3)

El Ashkar, S, Schwaller, J, Pieters, T, Goossens, S, Demeulemeester, J, Christ, F, Van Belle, S, Juge, S, Boeckx, N, Engelman, A, Van Vlierberghe, P, Debyser, Z, De Rijck, J.
LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis
Blood 131, 95-107, 2018. (Epub 2017 Oct 30)

Renard, M, Vanhauwaert, S, Vanhomwegen, M, Rihani, A, Vandamme, N, Goossens, S, Berx, G, Van Vlierberghe, P, Haigh, JJ, Decaesteker, B, Van Laere, J, Lambertz, I, Speleman, F, Vandesompele, J, Willaert, A.
Expressed repetitive elements are broadly applicable reference targets for normalization of reverse transcription-qPCR data in mice
Sci Rep 8, 7642, 2018. (Epub 2018 May 16)

Scott, CL, T'Jonck, W, Martens, L, Todorov, H, Sichien, D, Soen, B, Bonnardel, J, De Prijck, S, Vandamme, N, Cannoodt, R, Saelens, W, Vanneste, B, Toussaint, W, De Bleser, P, Takahashi, N, Vandenabeele, P, et al., Lambrecht, BN, De Baetselier, P, Milling, SWF, Van Ginderachter, JA, Malissen, B, Berx, G, Beschin, A, Saeys, Y, Guilliams, M.
The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages
Immunity 49, 312-325, 2018. (Epub 2018 Jul 31)

Skrypek, N, Bruneel, K, Vandewalle, C, De Smedt, E, Soen, B, Loret, N, Taminau, J, Goossens, S, Vandamme, N, Berx, G.
ZEB2 stably represses RAB25 expression through epigenetic regulation by SIRT1 and DNMTs during epithelial-to-mesenchymal transition
Epigenetics Chromatin 11, 70, 2018. (Epub 2018 Nov 16)

Consortium, E-T, Van Deun, J, Mestdagh, P, Agostinis, P, Akay, O, Anand, S, Anckaert, J, Martinez, ZA, Baetens, T, Beghein, E, Bertier, L, Berx, G, Boere, J, al., E, De Smedt, E, al., E, Soen, B, al., E, Van Vliet, AR, Vandamme, N, et al..
EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research
Nat Methods 14, 228-232, 2017. (Epub 2017 Feb 28)

Devos, M, Gilbert, B, Denecker, G, Leurs, K, Mc Guire, C, Lemeire, K, Hochepied, T, Vuylsteke, M, Lambert, J, Van Den Broecke, C, Libbrecht, L, Haigh, J, Berx, G, Lippens, S, Vandenabeele, P, Declercq, W.
Elevated DeltaNp63alpha levels facilitate epidermal and biliary oncogenic transformation
J Invest Dermatol 137, 494-505, 2017. (Epub 2016 Oct 7)

Goossens, S, Peirs, S, Van Loocke, W, Wang, J, Takawy, M, Matthijssens, F, Sonderegger, SE, Haigh, K, Nguyen, T, Vandamme, N, Costa, M, Carmichael, C, Van Nieuwerburgh, F, Deforce, D, Kleifeld, O, Curtis, DJ, Berx, G, Van Vlierberghe, P, Haigh, JJ.
Oncogenic ZEB2 activation drives sensitivity towards KDM1A inhibition in T-cell acute lymphoblastic leukemia
Blood 129, 981-990, 2017. (Epub 2017 Jan 9)

Goossens, S, Vandamme, N, Van Vlierberghe, P, Berx, G.
EMT transcription factors in cancer development re-evaluated: Beyond EMT and MET
Biochim Biophys Acta 1868, 584-591, 2017. (Epub 2017 Jun 29)

Kohler, C, Nittner, D, Rambow, F, Radaelli, E, Stanchi, F, Vandamme, N, Baggiolini, A, Sommer, L, Berx, G, van den Oord, JJ, Gerhardt, H, Blanpain, C, Marine, JC.
Mouse Cutaneous Melanoma Induced by Mutant BRaf Arises from Expansion and Dedifferentiation of Mature Pigmented Melanocytes
Cell Stem Cell 21, 679-693, 2017. (Epub 2017 Oct 12)

Li, J, Riedt, T, Goossens, S, Carrillo Garcia, C, Szczepanski, S, Brandes, M, Pieters, T, Dobrosch, L, Gutgemann, I, Farla, N, Radaelli, E, Hulpiau, P, Mallela, N, Frohlich, H, La Starza, R, Matteucci, C, Chen, T, Brossart, P, Mecucci, C, et al..
The EMT transcription factor Zeb2 controls adult murine hematopoietic differentiation by regulating cytokine signaling
Blood 129, 460-472, 2017. (Epub 2016 Sep 28)

Peirs, S, Frismantas, V, Matthijssens, F, Van Loocke, W, Pieters, T, Vandamme, N, Lintermans, B, Dobay, MP, Berx, G, Poppe, B, Goossens, S, Bornhauser, BC, Bourquin, JP, Van Vlierberghe, P.
Targeting BET proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia
Leukemia 31, 2037-2047, 2017. (Epub 2017 Feb 3 )

Pieters, T, Haenebalcke, L, Bruneel, K, Vandamme, N, Hochepied, T, van Hengel, J, Wirth, D, Berx, G, Haigh, JJ, van Roy, F, Goossens, S.
Structure-function Studies in Mouse Embryonic Stem Cells Using Recombinase-mediated Cassette Exchange
J Vis Exp , 122, 2017. (Epub 2017 Apr 27)

Skrypek, N, Goossens, S, De Smedt, E, Vandamme, N, Berx, G.
Epithelial-to-Mesenchymal Transition: Epigenetic Reprogramming Driving Cellular Plasticity
Trends Genet 33, 943-959, 2017. (Epub 2017 Sep 14)

Stryjewska, A, Dries, R, Pieters, T, Verstappen, G, Conidi, A, Coddens, K, Francis, A, Umans, L, van, IWF, Berx, G, van Grunsven, LA, Grosveld, F, Goossens, S, Haigh, JJ, Huylebroeck, D.
Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells
Stem Cells 35, 611-625, 2017. (Epub 2016 Oct 14)

Vergauwen, G, Dhondt, B, Van Deun, J, De Smedt, E, Berx, G, Timmerman, E, Gevaert, K, Miinalainen, I, Cocquyt, V, Braems, G, Van den Broecke, R, Denys, H, De Wever, O, Hendrix, A.
Confounding factors of ultrafiltration and protein analysis in extracellular vesicle research
Sci Rep 7, 2704, 2017. (Epub 2017 Jun 2)

Aaes, TL, Kaczmarek, A, Delvaeye, T, De Craene, B, De Koker, S, Heyndrickx, L, Delrue, I, Taminau, J, Wiernicki, B, De Groote, P, Garg, AD, Leybaert, L, Grooten, J, Bertrand, MJ, Agostinis, P, Berx, G, Declercq, W, Vandenabeele, P, Krysko, DV.
Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity
Cell Rep 15, 274-287, 2016. (Epub 2016 Mar 30)

Bouhy, D, Geuens, T, De Winter, V, Almeida-Souza, L, Katona, I, Weis, J, Hochepied, T, Goossens, S, Haigh, J, Janssens, S, Timmerman, V.
Characterization of New Transgenic Mouse Models for Two Charcot-Marie-Tooth-Causing HspB1 Mutations using the Rosa26 Locus
Journal of Neuromuscular Diseases 3, 183-200, 2016. (Epub 2016 May 27)

Bourcy, M, Suarez-Carmona, M, Lambert, J, Francart, ME, Schroeder, H, Delierneux, C, Skrypek, N, Thompson, EW, Jerusalem, G, Berx, G, Thiry, M, Blacher, S, Hollier, BG, Noel, A, Oury, C, Polette, M, Gilles, C.
Tissue factor induced by epithelial-mesenchymal transition triggers a pro-coagulant state that drives metastasis of circulating tumor cells
Cancer Res 76, 4270-4282, 2016. (Epub 2016 May 24)

Goossens, S, Van Vlierberghe, P.
Overcoming Steroid Resistance in T Cell Acute Lymphoblastic Leukemia
PLoS Med 13, e1002208, 2016. (Epub 2016 Dec 20)

Helsmoortel, HH, De Moerloose, B, Pieters, T, Ghazavi, F, Bresolin, S, Cave, H, de Vries, A, de Haas, V, Flotho, C, Labarque, V, Niemeyer, C, De Paepe, P, Van Roy, N, Stary, J, van den Heuvel-Eibrink, MM, Benoit, Y, Schulte, J, Goossens, S, Berx, G, et al., Van Vlierberghe, P, Lammens, T.
LIN28B is over-expressed in specific subtypes of paediatric leukaemia and regulates lncRNA H19
Haematologica 101, E240-E244, 2016. (Epub 2016 Mar 11)

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