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Publications from this research unit

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Baudhuin, H, Puttemans, J, Hanssens, H, Vanwolleghem, P, Hernot, S, Raes, G, Xavier, C, Lahoutte, T, Debie, P.
Decorating sdAbs with Chelators: Effect of Conjugation on Biodistribution and Functionality
Pharmaceuticals (Basel) 14, 407, 2021. (Epub 2021 Apr 25)

Carbo, JM, Leon, TE, Font-Diaz, J, De la Rosa, JV, Castrillo, A, Picard, FR, Staudenraus, D, Huber, M, Cedo, L, Escola-Gil, JC, Campos, L, Bakiri, L, Wagner, EF, Caelles, C, Stratmann, T, Van Ginderachter, JA, Valledor, AF.
Pharmacological activation of LXR alters the expression profile of tumor-associated macrophages and the abundance of regulatory T cells in the tumor microenvironment
Cancer Res 81, 968-985, 2021. (Epub 2020 Dec 23)

Germanova, D, Keirsse, J, Kohler, A, Hastir, JF, Demetter, P, Delbauve, S, Elkrim, Y, Verset, L, Larbanoix, L, Preyat, N, Laurent, S, Nedospasov, S, Donckier, V, Van Ginderachter, JA, Flamand, V.
Myeloid TNF and HO-1 regulate the progression of colorectal liver metastases during hepatic ischemia-reperfusion
Int J Cancer 148, 12761288, 2021. (Epub 2020 Oct 10)

Kim, JS, Kolesnikov, M, Peled-Hajaj, S, Scheyltjens, I, Xia, Y, Trzebanski, S, Haimon, Z, Shemer, A, Lubart, A, Van Hove, H, Chappell-Maor, L, Boura-Halfon, S, Movahedi, K, Blinder, P, Jung, S.
A Binary Cre Transgenic Approach Dissects Microglia and CNS Border-Associated Macrophages
Immunity 54, 176-190, 2021. (Epub 2020 Dec 16)

Kiss, M, Vande Walle, L, Saavedra, PHV, Lebegge, E, Van Damme, H, Murgaski, A, Qian, J, Ehling, M, Pretto, S, Bolli, E, Keirsse, J, Bardet, PMR, Arnouk, SM, Elkrim, Y, Schmoetten, M, Brughmans, J, Debraekeleer, A, Fossoul, A, Boon, L, et al..
IL1beta Promotes Immune Suppression in the Tumor Microenvironment Independent of the Inflammasome and Gasdermin D
Cancer Immunol Res 9, 309-323, 2021. (Epub 2020 Dec 23)

Lahmar, Q, Schouppe, E, Morias, Y, Van Overmeire, E, De Baetselier, P, Movahedi, K, Laoui, D, Sarukhan, A, Van Ginderachter, JA.
Monocytic myeloid-derived suppressor cells home to tumor-draining lymph nodes via CCR2 and locally modulate the immune response
Cell Immunol 362, 104296, 2021. (Epub 2021 Jan 30)

Lecocq, Q, Awad, RM, De Vlaeminck, Y, De Mey, W, Ertveldt, T, Goyvaerts, C, Raes, G, Thielemans, K, Keyaerts, M, Devoogdt, N, Breckpot, K.
Nanobody nuclear imaging allows noninvasive quantification of LAG-3 expression by tumor-infiltrating leukocytes and predicts response of immune checkpoint blockade
J Nucl Med , in press, 2021. (Epub 2021 Mar 12)

Pombo Antunes, AR, Scheyltjens, I, Lodi, F, Messiaen, J, Antoranz, A, Duerinck, J, Kancheva, D, Martens, L, De Vlaminck, K, Van Hove, H, Kjolner Hansen, SS, Bosisio, FM, Van der Borght, K, De Vleeschouwer, S, Sciot, R, Bouwens, L, Verfaillie, M, Vandamme, N, Vandenbroucke, RE, et al..
Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization
Nat Neurosci 24, 595-610, 2021. (Epub 2021 Mar 29)

Van Damme, H, Dombrecht, B, Kiss, M, Roose, H, Allen, E, Van Overmeire, E, Kancheva, D, Martens, L, Murgaski, A, Bardet, PMR, Blancke, G, Jans, M, Bolli, E, Martins, MS, Elkrim, Y, Dooley, J, Boon, L, Schwarze, JK, Tacke, F, Movahedi, K, Vandamme, N, Neyns, B, Ocak, S, Scheyltjens, I, Vereecke, L, Nana, FA, Merchiers, P, Laoui, D, Van Ginderachter, JA.
Therapeutic depletion of CCR8(+) tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy
J Immunother Cancer 9, e001749, 2021. (Epub 2021 Feb)

Virga, F, Cappellesso, F, Stijlemans, B, Henze, AT, Trotta, R, Van Audenaerde, J, Mirchandani, AS, Sanchez-Garcia, MA, Vandewalle, J, Orso, F, Riera-Domingo, C, Griffa, A, Ivan, C, Smits, E, Laoui, D, Martelli, F, Langouche, L, Van den Berghe, G, Feron, O, et al..
Macrophage miR-210 induction and metabolic reprogramming in response to pathogen interaction boost life-threatening inflammation
Sci Adv 7, eabf0466, 2021. (Epub 2021 May 7)

Zheng, F, Zhou, J, Ouyang, Z, Zhang, J, Wang, X, Muyldermans, S, Van Ginderachter, J, Devoogdt, N, Wen, Y, Schoonooghe, S, Raes, G.
Development and Characterization of Nanobodies Targeting the Kupffer Cell
Front Immunol 12, 641819, 2021. (Epub 2021 Feb 22)

Bridoux, J, Broos, K, Lecocq, Q, Debie, P, Martin, C, Ballet, S, Raes, G, Neyt, S, Vanhove, C, Breckpot, K, Devoogdt, N, Caveliers, V, Keyaerts, M, Xavier, C.
Anti-human PD-L1 Nanobody for Immuno-PET Imaging: Validation of a Conjugation Strategy for Clinical Translation
Biomolecules 10, E1388, 2020. (Epub 2020 Sep 29)

Deschoemaeker, S, Laoui, D.
IFNgamma signaling response in peripheral blood monocytes: A new prognostic biomarker for breast cancer?
EBioMedicine 53, 102690, 2020. (Epub 2020 Feb 25)

De Trez, C, Stijlemans, B, Bockstal, V, Cnops, J, Korf, H, Van Snick, J, Caljon, G, Muraille, E, Humphreys, IR, Boon, L, Van Ginderachter, JA, Magez, S.
A Critical Blimp-1-Dependent IL-10 Regulatory Pathway in T Cells Protects From a Lethal Pro-inflammatory Cytokine Storm During Acute Experimental Trypanosoma brucei Infection
Front Immunol 11, 1085, 2020. (Epub 2020 Jun 4)

De Vlaeminck, Y, Bonelli, S, Awad, RM, Dewilde, M, Rizzolio, S, Lecocq, Q, Bolli, E, Santos, AR, Laoui, D, Schoonooghe, S, Tamagnone, L, Goyvaerts, C, Mazzone, M, Breckpot, K, Van Ginderachter, JA.
Targeting Neuropilin-1 with Nanobodies Reduces Colorectal Carcinoma Development
Cancers (Basel) 12, 3582, 2020. (Epub 2020 Nov 30)

D'Huyvetter, M, De Vos, J, Caveliers, V, Vaneycken, I, Heemskerk, J, Duhoux, FP, Fontaine, C, Vanhoeij, M, Windhorst, AD, van der Aa, F, Hendrikse, NH, Eersels, JLE, Everaert, H, Gykiere, P, Devoogdt, N, Raes, G, Lahoutte, T, Keyaerts, M.
Phase I trial of (131)I-GMIB-Anti-HER2-VHH1, a new promising candidate for HER2-targeted radionuclide therapy in breast cancer patients
J Nucl Med , in press, 2020. (Epub 2020 Dec 4)

Kiss, M, Caro, AA, Raes, G, Laoui, D.
Systemic Reprogramming of Monocytes in Cancer
Front Oncol 10, 1399, 2020. (Epub 2020 Sep 17)

Lebegge, E, Arnouk, SM, Bardet, PMR, Kiss, M, Raes, G, Van Ginderachter, JA.
Innate Immune Defense Mechanisms by Myeloid Cells That Hamper Cancer Immunotherapy
Front Immunol 11, 1395, 2020. (Epub 2020 Jul 09)

Li, Z, Pinto Torres, JE, Goossens, J, Stijlemans, B, Sterckx, YG, Magez, S.
Development of a recombinase polymerase amplification lateral flow assay for the detection of active Trypanosoma evansi infections
PLoS Negl Trop Dis 14, e0008044, 2020. (Epub 2020 Feb 18)

Nguyen, PN, Tossounian, MA, Kovacs, DS, Thu, TT, Stijlemans, B, Vertommen, D, Pauwels, J, Gevaert, K, Angenon, G, Messens, J, Tompa, P.
Dehydrin ERD14 activates glutathione transferase Phi9 in Arabidopsis thaliana under osmotic stress
Biochim Biophys Acta Gen Subj 1864, 129506, 2020. (Epub 2019 Dec 20)

Pombo Antunes, AR, Scheyltjens, I, Duerinck, J, Neyns, B, Movahedi, K, Van Ginderachter, JA.
Understanding the glioblastoma immune microenvironment as basis for the development of new immunotherapeutic strategies
Elife 9, e52176, 2020. (Epub 2020 Feb 4)

Qian, J, Olbrecht, S, Boeckx, B, Vos, H, Laoui, D, Etlioglu, E, Wauters, E, Pomella, V, Verbandt, S, Busschaert, P, Bassez, A, Franken, A, Bempt, MV, Xiong, J, Weynand, B, van Herck, Y, Antoranz, A, Bosisio, FM, Thienpont, B, et al..
A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling
Cell Res , in press, 2020. (Epub 2020 Jun 19)

Raaymakers, C, Stijlemans, B, Martin, C, Zaman, S, Ballet, S, Martel, A, Pasmans, F, Roelants, K.
A New Family of Diverse Skin Peptides from the Microhylid Frog Genus Phrynomantis
Molecules 25, 912, 2020. (Epub 2020 Feb 18)

Romao, E, Krasniqi, A, Maes, L, Vandenbrande, C, Sterckx, YG, Stijlemans, B, Vincke, C, Devoogdt, N, Muyldermans, S.
Identification of Nanobodies against the Acute Myeloid Leukemia Marker CD33
Int J Mol Sci 21, 310, 2020. (Epub 2020 Jan 2)

Scherger, M, Bolli, E, Pombo Antunes, AR, Arnouk, S, Stickdorn, J, Van Driessche, A, Schild, H, Grabbe, S, De Geest, BG, Van Ginderachter, JA, Nuhn, L.
Transient Multivalent Nanobody Targeting to CD206-Expressing Cells via PH-Degradable Nanogels
Cells 9, E2222, 2020. (Epub 2020 Oct 1)

Shemer, A, Scheyltjens, I, Frumer, GR, Kim, JS, Grozovski, J, Ayanaw, S, Dassa, B, Van Hove, H, Chappell-Maor, L, Boura-Halfon, S, Leshkowitz, D, Mueller, W, Maggio, N, Movahedi, K, Jung, S.
Interleukin-10 Prevents Pathological Microglia Hyperactivation following Peripheral Endotoxin Challenge
Immunity 53, 1033-1049 e7, 2020. (Epub 2020 Oct 12)

Stijlemans, B, Korf, H, De Baetselier, P, Brys, L, Van Ginderachter, JA, Magez, S, De Trez, C.
Hepatocyte-derived IL-10 plays a crucial role in attenuating pathogenicity during the chronic phase of T. congolense infection
PLoS Pathog 16, e1008170, 2020. (Epub 2020 Feb 3)

Tipanee, J, Di Matteo, M, Tulalamba, W, Samara-Kuko, E, Keirsse, J, Van Ginderachter, JA, Chuah, MK, VandenDriessche, T.
Validation of miR-20a as a Tumor Suppressor Gene in Liver Carcinoma Using Hepatocyte-Specific Hyperactive piggyBac Transposons
Mol Ther Nucleic Acids 19, 1309-1329, 2020. (Epub 2020 Mar 6)

Van Hove, H, Pombo Antunes, AR, De Vlaminck, K, Scheyltjens, I, Van Ginderachter, JA, Movahedi, K.
Identifying the variables that drive tamoxifen-independent CreERT2 recombination: Implications for microglial fate mapping and gene deletions
Eur J Immunol 50, 459-463, 2020. (Epub 2019 Nov 30)

Bieniasz-Krzywiec, P, Martin-Perez, R, Ehling, M, Garcia-Caballero, M, Pinioti, S, Pretto, S, Kroes, R, Aldeni, C, Di Matteo, M, Prenen, H, Tribulatti, MV, Campetella, O, Smeets, A, Noel, A, Floris, G, Van Ginderachter, JA, Mazzone, M.
Podoplanin-Expressing Macrophages Promote Lymphangiogenesis and Lymphoinvasion in Breast Cancer
Cell Metab 30, 917-936, 2019. (Epub 2019 Aug 19)

Bolli, E, D'Huyvetter, M, Murgaski, A, Berus, D, Stange, G, Clappaert, EJ, Arnouk, S, Pombo Antunes, AR, Krasniqi, A, Lahoutte, T, Goncalves, A, Vuylsteke, M, Raes, G, Devoogdt, N, Movahedi, K, Van Ginderachter, JA.
Stromal-targeting radioimmunotherapy mitigates the progression of therapy-resistant tumors
J Control Release 314, 1-11, 2019. (Epub 2019 Oct 15)

Bonnardel, J, T'Jonck, W, Gaublomme, D, Browaeys, R, Scott, CL, Martens, L, Vanneste, B, De Prijck, S, Nedospasov, SA, Kremer, A, Van Hamme, E, Borghgraef, P, Toussaint, W, De Bleser, P, Mannaerts, I, Beschin, A, van Grunsven, LA, Lambrecht, BN, Taghon, T, et al..
Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche
Immunity 51, 638-654, 2019. (Epub 2019 Sep 24)

Broos, K, Lecocq, Q, Keersmaecker, B, Raes, G, Corthals, J, Lion, E, Thielemans, K, Devoogdt, N, Keyaerts, M, Breckpot, K.
Single Domain Antibody-Mediated Blockade of Programmed Death-Ligand 1 on Dendritic Cells Enhances CD8 T-cell Activation and Cytokine Production
Vaccines (Basel) 7, 85, 2019. (Epub 2019 Aug 7)

Broos, K, Lecocq, Q, Xavier, C, Bridoux, J, Nguyen, TT, Corthals, J, Schoonooghe, S, Lion, E, Raes, G, Keyaerts, M, Devoogdt, N, Breckpot, K.
Evaluating a Single Domain Antibody Targeting Human PD-L1 as a Nuclear Imaging and Therapeutic Agent
Cancers (Basel) 11, 6, 2019. (Epub 2019 Jun 21)

Bruger, AM, Dorhoi, A, Esendagli, G, Barczyk-Kahlert, K, van der Bruggen, P, Lipoldova, M, Perecko, T, Santibanez, J, Saraiva, M, Van Ginderachter, JA, Brandau, S.
How to measure the immunosuppressive activity of MDSC: assays, problems and potential solutions
Cancer Immunol Immunother 68, 631-644, 2019. (Epub 2018 May 21)

De Veirman, K, Menu, E, Maes, K, De Beule, N, De Smedt, E, Maes, A, Vlummens, P, Fostier, K, Kassambara, A, Moreaux, J, Van Ginderachter, JA, De Bruyne, E, Vanderkerken, K, Van Valckenborgh, E.
Myeloid-derived suppressor cells induce multiple myeloma cell survival by activating the AMPK pathway
Cancer Lett 442, 233-241, 2019. (Epub 2018 Nov 9)

De Vlaeminck, Y, Lecocq, Q, Giron, P, Heirman, C, Geeraerts, X, Bolli, E, Movahedi, K, Massa, S, Schoonooghe, S, Thielemans, K, Goyvaerts, C, Van Ginderachter, JA, Breckpot, K.
Single-domain antibody fusion proteins can target and shuttle functional proteins into macrophage mannose receptor expressing macrophages
J Control Release 299, 107-120, 2019. (Epub 2019 Feb 21)

Hanoteau, A, Newton, JM, Krupar, R, Huang, C, Liu, HC, Gaspero, A, Gartrell, RD, Saenger, YM, Hart, TD, Santegoets, SJ, Laoui, D, Spanos, C, Parikh, F, Jayaraman, P, Zhang, B, Van der Burg, SH, Van Ginderachter, JA, Melief, CJM, Sikora, AG.
Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy
J Immunother Cancer 7, 10, 2019. (Epub 2019 Jan 15)

Kariuki, CK, Stijlemans, B, Magez, S.
The Trypanosomal Transferrin Receptor of Trypanosoma Brucei-A Review
Trop Med Infect Dis 4, 4, 2019. (Epub 2019 Oct 1)

Kovacs, P, Csonka, T, Kovacs, T, Sari, Z, Ujlaki, G, Sipos, A, Karanyi, Z, Szeocs, D, Hegedus, C, Uray, K, Janko, L, Kiss, M, Kiss, B, Laoui, D, Virag, L, Mehes, G, Bai, P, Miko, E.
Lithocholic Acid, a Metabolite of the Microbiome, Increases Oxidative Stress in Breast Cancer
Cancers (Basel) 11, 9, 2019. (Epub 2019 Aug 27)

Laoui, D, Van Overmeire, E, Abels, C, Keirsse, J, Van Ginderachter, JA.
Adoptive Transfer of Monocytes Sorted from Bone Marrow
Bio-Protocol 9, , 2019. (Epub 2019 Jan 5)

Lecocq, Q, De Vlaeminck, Y, Hanssens, H, D'Huyvetter, M, Raes, G, Goyvaerts, C, Keyaerts, M, Devoogdt, N, Breckpot, K.
Theranostics in immuno-oncology using nanobody derivatives
Theranostics 9, 7772-7791, 2019. (Epub 2019 Oct 15)

Lecocq, Q, Zeven, K, De Vlaeminck, Y, Martens, S, Massa, S, Goyvaerts, C, Raes, G, Keyaerts, M, Breckpot, K, Devoogdt, N.
Noninvasive Imaging of the Immune Checkpoint LAG-3 Using Nanobodies, from Development to Pre-Clinical Use
Biomolecules 9, , 2019. (Epub 2019 Sep 29)

Murgaski, A, Bardet, PMR, Arnouk, SM, Clappaert, EJ, Laoui, D.
Unleashing Tumour-Dendritic Cells to Fight Cancer by Tackling Their Three A's: Abundance, Activation and Antigen-Delivery
Cancers (Basel) 11, 5, 2019. (Epub 2019 May 14)

Newton, JM, Hanoteau, A, Liu, HC, Gaspero, A, Parikh, F, Gartrell-Corrado, RD, Hart, TD, Laoui, D, Van Ginderachter, JA, Dharmaraj, N, Spanos, WC, Saenger, Y, Young, S, Sikora, AG.
Immune microenvironment modulation unmasks therapeutic benefit of radiotherapy and checkpoint inhibition
J Immunother Cancer 7, 216, 2019. (Epub 2019 Aug 13)

Senders, ML, Hernot, S, Carlucci, G, van de Voort, JC, Fay, F, Calcagno, C, Tang, J, Alaarg, A, Zhao, Y, Ishino, S, Palmisano, A, Boeykens, G, Meerwaldt, AE, Sanchez-Gaytan, BL, Baxter, S, Zendman, L, Lobatto, ME, et al., Raes, G, et al..
Nanobody-Facilitated Multiparametric PET/MRI Phenotyping of Atherosclerosis
JACC Cardiovasc Imaging 12, 2015-2026, 2019. (Epub 2018 Oct 12)

Umansky, V, Adema, GJ, Baran, J, Brandau, S, Van Ginderachter, JA, Hu, X, Jablonska, J, Mojsilovic, S, Papadaki, HA, Pico de Coana, Y, Santegoets, KCM, Santibanez, JF, Serre, K, Si, Y, Sieminska, I, Velegraki, M, Fridlender, ZG.
Interactions among myeloid regulatory cells in cancer
Cancer Immunol Immunother 68, 645-660, 2019. (Epub 2018 Jul 12)

Van Hove, H, Martens, L, Scheyltjens, I, De Vlaminck, K, Pombo Antunes, AR, De Prijck, S, Vandamme, N, De Schepper, S, Van Isterdael, G, Scott, CL, Aerts, J, Berx, G, Boeckxstaens, GE, Vandenbroucke, RE, Vereecke, L, Moechars, D, Guilliams, M, Van Ginderachter, JA, Saeys, Y, Movahedi, K.
A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment
Nat Neurosci 22, 10211035, 2019. (Epub 2019 May 6)

Varasteh, Z, Mohanta, S, Li, Y, Lopez Armbruster, N, Braeuer, M, Nekolla, SG, Habenicht, A, Sager, HB, Raes, G, Weber, W, Hernot, S, Schwaiger, M.
Targeting mannose receptor expression on macrophages in atherosclerotic plaques of apolipoprotein E-knockout mice using (68)Ga-NOTA-anti-MMR nanobody: non-invasive imaging of atherosclerotic plaques
EJNMMI Res 9, 5, 2019. (Epub 2019 Jan 21)

Vriens, K, Christen, S, Parik, S, Broekaert, D, Yoshinaga, K, Talebi, A, Dehairs, J, Escalona-Noguero, C, Schmieder, R, Cornfield, T, Charlton, C, Romero-Perez, L, Rossi, M, Rinaldi, G, Orth, MF, Boon, R, Kerstens, A, Kwan, SY, Faubert, B, et al..
Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity
Nature 566, 403406, 2019. (Epub 2019 Feb 6)

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