Title: Publications by unit

Publications from this research unit

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Lu, Z, Van Eeckhoutte, HP, Liu, G, Nair, PM, Jones, B, Gillis, CM, Nalkurthi, BC, Verhamme, F, Buyle-Huybrecht, T, Vandenabeele, P, Vanden Berghe, T, Brusselle, GG, Murphy, JM, Wark, PA, Bracke, KR, Fricker, M, Hansbro, PM.
Necroptosis Signalling Promotes Inflammation, Airway Remodelling and Emphysema in COPD
Am J Respir Crit Care Med , in press, 2021. (Epub 2021 Jun 16)

Oltean, T, Van San, E, Divert, T, Vanden Berghe, T, Saelens, X, Maelfait, J, Takahashi, N, Vandenabeele, P.
Viral dosing of influenza A infection reveals involvement of RIPK3 and FADD, but not MLKL
Cell Death Dis 12, 471, 2021. (Epub 2021 May 11)

Adjemian, S, Oltean, T, Martens, S, Wiernicki, B, Goossens, V, Vanden Berghe, T, Cappe, B, Ladik, M, Riquet, FB, Heyndrickx, L, Bridelance, J, Vuylsteke, M, Vandecasteele, K, Vandenabeele, P.
Ionizing radiation results in a mixture of cellular outcomes including mitotic catastrophe, senescence, methuosis, and iron-dependent cell death
Cell Death Dis 11, 1003, 2020. (Epub 2020 Nov 23)

De Samber, B, Vanden Berghe, T, Meul, E, Bauters, S, Seyrich, M, Smet, J, De Paepe, B, da Silva, JC, Bohic, S, Cloetens, P, Van Coster, R, Vandenabeele, P, Vincze, L.
Nanoscopic X-ray imaging and quantification of the iron cellular architecture within single fibroblasts of Friedreich's ataxia patients
J Synchrotron Radiat 27, 185-198, 2020. (Epub 2020 Jan 1)

Hassannia, B, Logie, E, Vandenabeele, P, Vanden Berghe, T, Vanden Berghe, W.
Withaferin A: from Ayurvedic folk medicine to preclinical anti-cancer drug
Biochem Pharmacol 173, 113602, 2020. (Epub 2019 Aug 9)

Hassannia, B, Van Coillie, S, Vanden Berghe, T.
Ferroptosis: biological rust of lipid membranes
Antioxid Redox Signal , in press, 2020. (Epub 2020 Aug 18)

Jacobs, W, Lammens, M, Kerckhofs, A, Voets, E, Van San, E, Van Coillie, S, Peleman, C, Mergeay, M, Sirimsi, S, Matheeussen, V, Jansens, H, Baar, I, Vanden Berghe, T, Jorens, PG.
Fatal lymphocytic cardiac damage in coronavirus disease 2019 (COVID-19): autopsy reveals a ferroptosis signature
ESC Heart Fail 10, 1279-1287, 2020. (Epub 2020 Sep 22)

Roberti, MP, Yonekura, S, Duong, CPM, Picard, M, Ferrere, G, Tidjani Alou, M, , et al., Kourula, S, et al., Vanden Berghe, T, Ghiringhelli, F, Vandenabeele, P, Kroemer, G, Zitvogel, L.
Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer
Nat Med 26, 919-931, 2020. (Epub 2020 May 25)

Van Coillie, S, Wiernicki, B, Xu, J.
Molecular and Cellular Functions of CTLA-4
Adv Exp Med Biol 1248, 7-32, 2020. (Epub 2020 Mar 18)

Wiernicki, B, Dubois, H, Tyurina, YY, Hassannia, B, Bayir, H, Kagan, VE, Vandenabeele, P, Wullaert, A, Vanden Berghe, T.
Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis
Cell Death Dis 11, 922, 2020. (Epub 2020 Oct 27)

Boeltz, S, Amini, P, Anders, HJ, Andrade, F, Bilyy, R, Chatfield, S, Cichon, I, Clancy, DM, Desai, J, et al., Maueroder, C, et al. , Vanden Berghe, T, Vandenabeele, P, Hahn, J, Hidalgo, A, Hoffmann, MH, Kaplan, MJ, Knight, JS, Kolaczkowska, E, Kubes, P, et al..
To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps
Cell Death Differ 26, 395-408, 2019. (Epub 2019 Jan 8)

Elvas, F, Vanden Berghe, T, Adriaenssens, Y, Vandenabeele, P, Augustyns, K, Staelens, S, Stroobants, S, Van der Veken, P, Wyffels, L.
Caspase-3 probes for PET imaging of apoptotic tumor response to anticancer therapy
Org Biomol Chem 17, 4801-4824, 2019. (Epub 2019 Apr 29)

Hassannia, B, Vandenabeele, P, Vanden Berghe, T.
Targeting Ferroptosis to Iron Out Cancer
Cancer Cell 35, 830-849, 2019. (Epub 2019 May 16)

Tang, D, Kang, R, Vanden Berghe, T, Vandenabeele, P, Kroemer, G.
The molecular machinery of regulated cell death
Cell Res 29, 347-364, 2019. (Epub 2019 Apr 6)

Vanden Berghe, T, Hoste, E.
Paving the way for precision medicine v2.0 in intensive care by profiling necroinflammation in biofluids
Cell Death Differ 26, 8398, 2019. (Epub 2018 Sep 10)

Webb, LV, Barbarulo, A, Huysentruyt, J, Vanden Berghe, T, Takahashi, N, Ley, S, Vandenabeele, P, Seddon, B.
Survival of Single Positive Thymocytes Depends upon Developmental Control of RIPK1 Kinase Signaling by the IKK Complex Independent of NF-kappaB
Immunity 50, 348-361, 2019. (Epub 2019 Jan 23)

Annibaldi, A, Wicky John, S, Vanden Berghe, T, Swatek, KN, Ruan, J, Liccardi, G, Bianchi, K, Elliott, PR, Choi, SM, Van Coillie, S, Bertin, J, Wu, H, Komander, D, Vandenabeele, P, Silke, J, Meier, P.
Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2
Mol Cell 69, 566-580, 2018. (Epub 2018 Feb 15)

De Samber, B, Meul, E, Laforce, B, De Paepe, B, Smet, J, De Bruyne, M, De Rycke, R, Bohic, S, Cloetens, P, Van Coster, R, Vandenabeele, P, Vanden Berghe, T.
Nanoscopic X-ray fluorescence imaging and quantification of intracellular key-elements in cryofrozen Friedreich's ataxia fibroblasts
PLoS One 13, e0190495, 2018. (Epub 2018 Jan 17)

Devisscher, L, Van Coillie, S, Hofmans, S, Van Rompaey, D, Goossens, K, Meul, E, Maes, L, De Winter, H, Van Der Veken, P, Vandenabeele, P, Vanden Berghe, T, Augustyns, K.
Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy
J Med Chem 61, 10126-10140, 2018. (Epub 2018 Nov 21)

Galluzzi, L, Vitale, I, Aaronson, SA, Abrams, JM, Adam, D, Agostinis, P, Alnemri, ES, et al., Bertrand, MJM, et al., Vanden Berghe, T, Vandenabeele, P, et al., Kroemer,G.
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
Cell Death Differ 25, 486-541, 2018. (Epub 2018 Jan 23)

Hassannia, B, Wiernicki, B, Ingold, I, Qu, F, Van Herck, S, Tyurina, YY, Bayir, H, Abhari, BA, Angeli, JPF, Choi, SM, Meul, E, Heyninck, K, et al., Lahtela-Kakkonen, M, Van Camp, G, Krysko, DV, Ekert, PG, Fulda, S,De Geest, B.G., Vanden Berghe, W., Vandenabeele, P., Vanden Berghe, T.
Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma
J Clin Invest 128, 3341-3355, 2018. (Epub 2018 Jun 25)

Saavedra, PHV, Huang, L, Ghazavi, F, Kourula, S, Vanden Berghe, T, Takahashi, N, Vandenabeele, P, Lamkanfi, M.
Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis
Nat Commun 9, 4846, 2018. (Epub 2018 Nov 19)

Vandenabeele, P, Declercq, W, Roelandt, R, Vanden Berghe, T.
MLKL Reveals Its Friendly Face: A Role in Nerve Regeneration
Mol Cell 72, 397-399, 2018. (Epub 2018 Nov 1)

Breyne, K, Steenbrugge, J, Demeyere, K, Vanden Berghe, T, Meyer, E.
Preconditioning with Lipopolysaccharide or Lipoteichoic Acid Protects against Staphylococcus aureus Mammary Infection in Mice
Front Immunol 8, 833, 2017. (Epub 2017 Jul 24)

Fearnhead, HO, Vandenabeele, P, Vanden Berghe, T.
How do we fit ferroptosis in the family of regulated cell death?
Cell Death Differ 24, 1991-1998, 2017. (Epub 2017 Oct 6)

Grootjans, S, Vanden Berghe, T, Vandenabeele, P.
Initiation and execution mechanisms of necroptosis: an overview
Cell Death Differ 24, 1184-1195, 2017. (Epub 2017 May 12)

Hariton, WVJ, Galichet, A, Vanden Berghe, T, Overmiller, AM, Mahoney, MG, Declercq, W, Muller, EJ.
Feasibility study for clinical application of caspase-3 inhibitors in Pemphigus vulgaris
Exp Dermatol 26, 1274-1277, 2017. (Epub 2017 Nov 3)

Kip, E, Naze, F, Suin, V, Vanden Berghe, T, Francart, A, Lamoral, S, Vandenabeele, P, Beyaert, R, Van Gucht, S, Kalai, M.
Impact of caspase-1/11, -3, -7, or IL-1beta/IL-18 deficiency on rabies virus-induced macrophage cell death and onset of disease
Cell Death Discov 3, 17012, 2017. (Epub 2017 Mar 6)

Linkermann, A, Stockwell, BR, Vanden Berghe, T.
Heavy Metal Suicide
Am J Physiol Renal Physiol 313, F959-F960, 2017. (Epub 2017 May 31)

Vanden Berghe, T, Kaiser, WJ.
RIPK1 prevents aberrant ZBP1-initiated necroptosis
Oncotarget 8, 1-2, 2017. (Epub 2017 Jan 3)

Grootjans, S, Hassannia, B, Delrue, I, Goossens, V, Wiernicki, B, Dondelinger, Y, Bertrand, MJ, Krysko, DV, Vuylsteke, M, Vandenabeele, P, Vanden Berghe, T.
A real-time fluorometric method for the simultaneous detection of cell death type and rate
Nat Protoc 11, 1444-1454, 2016. (Epub 2016 Jul 14)

Hofmans, S, Vanden Berghe, T, Devisscher, L, Hassannia, B, Lyssens, S, Joossens, J, Van der Veken, P, Vandenabeele, P, Augustyns, K.
Novel ferroptosis inhibitors with improved potency and ADME properties
J Med Chem 59, 2041-2053, 2016. (Epub 2015 Dec 22)

Vanden Berghe, T, Hassannia, B, Vandenabeele, P.
An outline of necrosome triggers
Cell Mol Life Sci 73, 2137-2152, 2016. (Epub 2016 Apr 6)

Babu, D, Leclercq, G, Goossens, V, Vanden Berghe, T, Van Hamme, E, Vandenabeele, P, Lefebvre, RA.
Mitochondria and NADPH oxidases are the major sources of TNF-alpha/cycloheximide-induced oxidative stress in murine intestinal epithelial MODE-K cells
Cell Signal 27, 1141-1158, 2015. (Epub 2015 Feb 26)

Vanden Berghe, T, Hulpiau, P, Martens, L, Vandenbroucke, RE, Van Wonterghem, E, Perry, SW, Bruggeman, I, Divert, T, Choi, SM, Vuylsteke, M, Shestopalov, VI, Libert, C, Vandenabeele, P.
Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice
Immunity 43, 200-209, 2015. (Epub 2015 Jul 21)

Vanden Berghe, T, Kaiser, WJ, Bertrand, MJ, Vandenabeele, P.
Molecular crosstalk between apoptosis, necroptosis, and survival signaling
Mol Cell Oncol 2, e975093, 2015. (Epub 2015 Apr 8)

Vanden Berghe, T, Linkermann, A.
Take my breath away: necrosis in kidney transplants kills the lungs!
Kidney Intl 87, 680-682, 2015. (Epub 2015 APr)

Vesela, B, Svandova, E, Vanden Berghe, T, Tucker, AS, Vandenabeele, P, Matalova, E.
Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue
J Mol Histol 46, 443-455, 2015. (Epub 2015 Aug 8)

Breyne, K, Cool, SK, Demon, D, Demeyere, K, Vanden Berghe, T, Vandenabeele, P, Carlsen, H, Van Den Broeck, W, Sanders, NN, Meyer, E.
Non-classical proIL-1beta activation during mammary gland infection is pathogen-dependent but Caspase-1 independent
PLoS One 9, e105680, 2014. (Epub 2014 Aug 27)

Galluzzi, L, Bravo-San Pedro, JM, Vitale, I, Aaronson, SA, Abrams, JM, Adam, D, Alnemri, ES, Altucci, L, Andrews, D, Annicchiarico-Petruzzelli, M, Baehrecke, EH, Bazan, NG, Bertrand, MJ, Bianchi, K, Blagosklonny, MV, Blomgren, K, Borner, C, Bredesen, DE, Brenner, C, Campanella, M, Candi, E, Cecconi, F, Chan, FK, Chandel, NS, Cheng, EH, Chipuk, JE, Cidlowski, JA, Ciechanover, A, Dawson, TM, Dawson, VL, De Laurenzi, V, De Maria, R, Debatin, KM, Di Daniele, N, Dixit, VM, Dynlacht, BD, El-Deiry, WS, Fimia, GM, Flavell, RA, Fulda, S, Garrido, C, Gougeon, ML, Green, DR, Gronemeyer, H, Hajnoczky, G, Hardwick, JM, Hengartner, MO, Ichijo, H, Joseph, B, Jost, PJ, Kaufmann, T, Kepp, O, Klionsky, DJ, Knight, RA, Kumar, S, Lemasters, JJ, Levine, B, Linkermann, A, Lipton, SA, Lockshin, RA, Lopez-Otin, C, Lugli, E, Madeo, F, Malorni, W, Marine, JC, Martin, SJ, Martinou, JC, Medema, JP, Meier, P, Melino, S, Mizushima, N, Moll, U, Munoz-Pinedo, C, Nunez, G, Oberst, A, Panaretakis, T, Penninger, JM, Peter, ME, Piacentini, M, Pinton, P, Prehn, JH, Puthalakath, H, Rabinovich, GA, Ravichandran, KS, Rizzuto, R, Rodrigues, CM, Rubinsztein, DC, Rudel, T, Shi, Y, Simon, HU, Stockwell, BR, Szabadkai, G, Tait, SW, Tang, HL, Tavernarakis, N, Tsujimoto, Y, Vanden Berghe, T, Vandenabeele, P, Villunger, A, Wagner, EF, Walczak, H, White, E, Wood, WG, Yuan, J, Zakeri, Z, Zhivotovsky, B, Melino, G, Kroemer, G.
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
Cell Death Differ 22, 58-73, 2014. (Epub 2014 Sep 19)

Jouan-Lanhouet, S, Riquet, F, Duprez, L, Vanden Berghe, T, Takahashi, N, Vandenabeele, P.
Necroptosis, in vivo detection in experimental disease models
Semin Cell Dev Biol 35C, 2-13, 2014. (Epub 2014 Aug 23)

Linkermann, A, Skouta, R, Himmerkus, N, Mulay, SR, Dewitz, C, De Zen, F, Prokai, A, Zuchtriegel, G, Krombach, F, Welz, PS, Weinlich, R, Vanden Berghe, T, Vandenabeele, P, Pasparakis, M, Bleich, M, Weinberg, JM, Reichel, CA, Brasen, JH, Kunzendorf, U, Anders, HJ, Stockwell, BR, Green, DR, Krautwald, S.
Synchronized renal tubular cell death involves ferroptosis
Proc Natl Acad Sci USA 111, 16836-16841, 2014. (Epub 2014 Nov 10)

Remijsen, Q, Goossens, V, Grootjans, S, Van den Haute, C, Vanlangenakker, N, Dondelinger, Y, Roelandt, R, Bruggeman, I, Goncalves, A, Bertrand, MJ, Baekelandt, V, Takahashi, N, Vanden Berghe, T, Vandenabeele, P.
Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis
Cell Death Dis 5, e1004, 2014. (Epub 2014 Jan 16)

Svandova, E, Lesot, H, Vanden Berghe, T, Tucker, AS, Sharpe, PT, Vandenabeele, P, Matalova, E.
Non-apoptotic functions of caspase-7 during osteogenesis
Cell Death Dis 5, e1366, 2014. (Epub 2014 Aug 14)

Vanden Berghe, T, Demon, D, Bogaert, P, Vandendriessche, B, Goethals, A, Depuydt, B, Vuylsteke, M, Roelandt, R, Van Wonterghem, E, Vandenbroecke, J, Choi, SM, Meyer, E, Krautwald, S, Declercq, W, Takahashi, N, Cauwels, A, Vandenabeele, P.
Simultaneous targeting of Interleukin-1 and -18 is required for protection against inflammatory and septic shock
Am J Respir Crit Care Med 189, 282-291, 2014. (Epub 2014 Jan 23)

Vanden Berghe, T, Linkermann, A, Jouan-Lanhouet, S, Walczak, H, Vandenabeele, P.
Regulated necrosis: the expanding network of non-apoptotic cell death pathways
Nat Rev Mol Cell Biol 15, 135-147, 2014. (Epub 2014 Jan 23)

Matalova, E, Lesot, H, Svandova, E, Vanden Berghe, T, Sharpe, PT, Healy, C, Vandenabeele, P, Tucker, AS.
Caspase-7 participates in differentiation of cells forming dental hard tissues
Dev Growth Differ 55, 615-621, 2013. (Epub 2013 May 29)

Vanden Berghe, T, Goethals, A, Demon, D, Bogaert, P, Mak, TW, Cauwels, A, Vandenabeele, P.
An inactivating caspase-11 passenger mutation muddles sepsis research
Am J Respir Crit Care Med 188, 120-121, 2013. (Epub 2013 Jul 1)

Vanden Berghe, T, Grootjans, S, Goossens, V, Dondelinger, Y, Krysko, DV, Takahashi, N, Vandenabeele, P.
Determination of apoptotic and necrotic cell death in vitro and in vivo
Methods 61, 117-129, 2013. (Epub 2013 Mar 6)

Vanden Berghe, T, Kersse, K, Vandenabeele, P.
Caspase-3 and Caspase-7
In Handbook of Proteolytic Enzymes. (Rawlings, N.D. & Salvesen, G.S., eds.), Oxford, Academic Press, pp. 2256-2265, 2013. (Epub 2013 Jan)

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