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“Molecular checkpoints controlling the onset and resolution of inflammation”

Defining the molecular and cellular checkpoints that control onset and resolution of inflammation is essential to understand the pathogenesis of immune-mediated inflammatory diseases and to identify novel therapeutic targets. Our work has identified key factors that initiate autoimmunity and promote onset of inflammatory diseases such as rheumatoid arthritis and systemic lupus erythematosus as well as important mechanisms that support tissue homeostasis and promote resolution of inflammation. By leveraging these insights, we aim to develop novel therapeutic approaches that are based on small molecules as well as on cell- and gene therapies.

From 18 Dec 2026 11:30
Until 18 Dec 2026 12:30
Speaker
Gerhard Krönke
Affiliation
Department of Rheumatology and Clinical Immunology, Charité, Berlin Medical School
Host Dirk Elewaut
Stream ID 876 4072 7198
Stream Password 475565

About the speaker

After graduating from the Medical University of Vienna in 2002, Gerhard Krönke worked as postdoctoral researcher at the Medical University of Vienna (2002-2004) and the University of Virginia, Charlottesville (2004-2006). From 2006-2015 he conducted his clinical training in Internal Medicine and subsequently in Rheumatology at the University Hospital Erlangen, where he worked as Senior Physician at the Department of Internal Medicine 3 from 2012-2023. In 2016, he was appointed Professor of Translational Immunology at the University of Erlangen-Nürnberg. In 2023 he moved to Berlin where he is now serving as chair and director of the Medical Department of Rheumatology and Clinical immunology at the Charité University Hospital Berlin. Gerhard Krönke´s research work focuses on the molecular mechanisms contributing to the development of immune mediated inflammatory diseases (IMIDs) such as rheumatoid arthritis and systemic lupus erythematosus. A particular focus of his research lies on the identification of novel therapeutic targets and treatment approaches, which resulted in the identification of a novel molecular mode of action of glucocorticoids as well as the introduction of novel therapeutic strategies such as CAR T cells and T cell engagers as newly emerging therapeutic principles for IMIDs. He received multiple awards as well as an ERC Starting grant and an ERC consolidator grant.

“Molecular checkpoints controlling the onset and resolution of inflammation”
Seminar