T follicular helper 13 (Tfh13) cells are a specialized subset of Tfh cells that promotes the production of high-affinity, anaphylactic IgE. In this talk, I will discuss our discovery of Tfh13 cells and our efforts to understand the signals that control their differentiation. I will focus on our recent work identifying lymph node ILC2s as an innate source of IL-4 that instructs Tfh13 differentiation, highlighting divergent requirements for Tfh13 and canonical Tfh2 cell responses. I will also discuss how the local immune environment regulates this pathway and present complementary studies defining cell-intrinsic mechanisms that restrain Tfh13 responses, including DOCK8 and STAT3, as well as IL-6 signaling as a negative regulator of Tfh13 differentiation.
Gowthaman Uthaman, PhD, is an Assistant Professor in the Department of Pathology at UMass Chan Medical School. He received his PhD from Jawaharlal Nehru University in India and completed his postdoctoral training at Yale University. During his postdoctoral work, he identified Tfh13 cells as a specialized T follicular helper cell population required for the production of high-affinity, anaphylactic IgE and uncovered a central role for cDC2s in priming Tfh cell responses. He established his independent laboratory at UMass Chan in October 2020, where his group studies how innate immune cells and cytokine signals regulate Tfh13 differentiation and pathogenic antibody responses, with the broader goal of understanding the mechanisms that distinguish protective from disease-causing humoral immunity. Gowthaman's research has been recognized with several awards and honors, including the Smith Award for Excellence in Biomedical Research, the Charles H. Hood Foundation Child Health Research Award, and the Gershon Fellowship.