This lecture is focused on a technology used to study cell interaction—using circular RNA barcodes that are transmitted between cells.
McManus's work has a strong technology component, and his lab uses systematic and synthetic approaches to conquer fundamental problems in understanding gene function in health and disease. He maintains a very diverse research program, encouraging students and postdocs and research technicians to follow their research interests, by developing new tools and approaches to solve long-standing problems in their field of interest. Having successfully trained in different areas (plant molecular biology, molecular parasitology, RNA biology, and human development/disease) his broad language for basic science has expanded his appreciation of systems biology. Consequently, the ability to integrate diverse sources of information has helped develop innovations and ideas that this team has shared with other labs, yielding high impact discoveries in multiple fields throughout my career. This includes several examples where he has derived novel approaches in team settings and applied them to basic biology that intersects complex biological systems.