Pierre Guermonprez has studied antigen presentation by dendritic cells to T cells, their role in anti-infectious immunity, and their developmental pathways in both murine and human models. In 2020 he shifted his focus on dendritic cells in cancer. In 2024, he joined the Immunology Department of Institut Pasteur where he is leading the “Dendritic cells and adaptive immunity” research unit addressing the basic biology of dendritic cells and exploring new avenues for harnessing their immunogenic function in vaccines and immunotherapies. His research group is focused on disentangling the diversity and dynamics of dendritic cell populations infiltrating solid tumors and identify actionable pathways of anti-tumor immunity. Specifically, which molecules and processes controlling the infiltration of tumor by dendritic cell precursors, the interaction of intra-tumoral dendritic cells with epithelial niches, their ability to migrate to lymph nodes and polarized T cells into anti-tumor effectors. He will present attempts at disentangling these processes and novel immunotherapeutic approaches based on this knowledge.