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In Vivo Human Immunity Models as a Lens on Tumor‑Associated Macrophages

This talk will present humanized mouse platforms and the use of CRISPR editing in human hematopoietic stem cells to model and perturb, in vivo, the gene networks that govern tumor‑associated macrophage differentiation and function. I will show how these systems enable precise dissection of human TAM biology and how the same approaches extend to broader questions in human immunity, including the impact of EBV infection on human myelopoiesis and the ontogeny of human γδ T cells.

From 05 Jun 2026 11:30
Until 05 Jun 2026 12:30
Location FSVMI building, seminar room
Speaker
Stanislas Goriely
Affiliation
Institute for Medical Immunology and Immunobiology Lab Université Libre de Bruxelles (ULB)
Host Bart Lambrecht
Stream ID 842 3087 4975
Stream Password 329898

About the speaker

Stanislas Goriely holds an M.D. (1999) and a Ph.D. in Medical Sciences (2004) from the Université libre de Bruxelles (ULB). He became Research Director at the FNRS and Professor at the ULB Faculty of Medicine and Sciences. His research focuses on the regulation of immune responses in inflammatory diseases and cancer, with broad expertise in transcriptional regulation, and systems immunology. His group has made important contributions to dendritic cell biology, the regulation of IL 12 family cytokines, mode of action of vaccine adjuvants and CD8 T cell memory. Current work uses advanced animal models to investigate transcriptional and epigenetic networks in mononuclear phagocytes in health and disease. The laboratory is increasingly centered on immuno oncology.

In Vivo Human Immunity Models as a Lens on Tumor‑Associated Macrophages
Seminar