Biology and modulation of human microglia in Alzheimer’s disease

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In this talk, Renzo Mancuso will guide you through the process to generating microglia humanised models, and he will discuss specific aspects of the biology of human microglia in Alzheimer’s disease.


From 15 Nov 2024 11:30
Until 15 Nov 2024 12:30
Location FSVMI building, seminar room

Speaker Renzo Mancuso
Affiliation Laboratory of Microglia and Inflammation in Neurological Disorders (MIND), VIB-Center for Molecular Neurology (CMN), VIB
Host Bart Lambrecht

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About the speaker

Renzo obtained his PhD in Neuroscience at the Autonomous University of Barcelona in the laboratory of Prof. Xavier Navarro at the group of Neuroplasticity and Regeneration. He performed his postdoctoral trainings in the laboratories of Prof. V. Hugh Perry at the University of Southampton (UK), and Prof. Bart De Strooper at the VIB-KU Leuven Center for Brain & Disease Research in Belgium. His scientific work is focused on the role of microglia in Alzheimer’s disease, linking human genetics with microglia function in iPSC-derived microglia and xenotransplantation models. His major findings are elucidating the detrimental role of microglia in the aggregation of tau and tau-induced cell death, the development and application of microglia humanized models for the study of genotype-phenotype interactions and several aspects of human microglial biology, in vivo, in neurodegenerative diseases. Renzo is currently Group Leader and Deputy Director at the VIB-Center for Molecular Neurology where he works on multiple basic and translational projects to dissect the role of microglia and neuroinflammation in Alzheimer’s and Frontotemporal dementia, using cellular systems to uncover major phenotypic modifications in microglia and building up from there into more complex in vivo chimeric models, and human primary samples.

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Seminar